The contribution of thiamine, pyridoxine and cyanocobalamine combination on nerve regeneration in rats with experimentally induced sciatic injury

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dc.contributor.authorBesalti, Ömer
dc.contributor.authorErgin, İrem
dc.contributor.authorÜnlü, Ece
dc.contributor.authorPekcan, Zeynep
dc.contributor.authorKoskan, Özgür
dc.date.accessioned2020-06-25T17:44:00Z
dc.date.available2020-06-25T17:44:00Z
dc.date.issued2007
dc.descriptionErgin, Irem/0000-0003-2373-5133; Besalti, Omer/0000-0002-7819-9094
dc.description.abstractThe aim of this study was to investigate the role of thiamine, pyridoxine and cyanocobalamine combination on nerve regeneration after experimentally induced crush injury in thirty adult, male wistar rats. Sciatic function index and Toe spreading reflex and nerve conduction studies on exposed sciatic nerve were carried out before sciatic crush injury and after three weeks of treatment. The experiment group received thiamine (33 mg kg(-1)), pyridoxine (33 mg kg(-1)) and cyanocobalamine (0.5 mg kg(-1)) injections intramuscularly for 3 weeks and the control group received equal volumes of saline injections. Toe-spreading reflex were better in the experiment group than the controls after treatment (p<0.05). There was no significant difference in regard to DL, DCMAP, PCMAP and NCV between both groups (p<0.05). In conclusion the beneficial effect of thiamine, pyridoxine and cyanocobalamine combination was not found in regard to the electrophysiological parameters measured. However clinical improvement was superior in the experiment group than the control group.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage214en_US
dc.identifier.issn1680-5593
dc.identifier.issue2en_US
dc.identifier.startpage210en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3976
dc.identifier.volume6en_US
dc.identifier.wosWOS:000253195400016
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherMedwell Onlineen_US
dc.relation.ispartofJournal Of Animal And Veterinary Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsciatic nerveen_US
dc.subjectcrushen_US
dc.subjectvitamin Ben_US
dc.subjectelectrophysiologyen_US
dc.subjectraten_US
dc.subjectthiamineen_US
dc.titleThe contribution of thiamine, pyridoxine and cyanocobalamine combination on nerve regeneration in rats with experimentally induced sciatic injuryen_US
dc.typeArticle

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