Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Children with Urinary Tract Infections

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dc.authoridDINDAR BADEM, NERMIN/0000-0002-5095-7818
dc.authoridcelikel acar, banu/0000-0002-1808-3655
dc.contributor.authorTursun, Serkan
dc.contributor.authorAlpcan, Aysegul
dc.contributor.authorOzsoy, Metin
dc.contributor.authorBadem, Nermin Dindar
dc.contributor.authorKandur, Yasar
dc.contributor.authorAcar, Banu Celikel
dc.date.accessioned2025-01-21T16:37:44Z
dc.date.available2025-01-21T16:37:44Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective The aim of the present study was to evaluate the diagnostic value of soluble triggering receptor on myeloid cells-1 as a novel marker for diagnosis of childhood urinary tract infections (UTI). Methods This study enrolled 30 pediatric patients diagnosed with acute febrile UTIs; 30 healthy children were included as the control group. The blood samples from the patients and healthy controls were collected for a soluble triggering receptor on myeloid cells-1 (sTREM-1) test. Results The study group was composed of 9 males and 21 females, and the mean age of the study population was 6.63.2 (range=1-14) years. sTREM-1 levels were significantly higher in UTI patients than in the controls (592 +/- 323 vs. 490 +/- 299 pg/mL, p=0.04). The receiver operating curve analysis revealed a cut-off value of soluble triggering receptor expressed on myeloid cells-1 of 514 ng/mL (area under the curve=0.562). When the cut-off value was taken 514 pg/mL, soluble triggering receptor expressed on myeloid cells-1 had a sensitivity of 57% and a specificity of 50% for the diagnosis of UTI. Conclusion The present study revealed that plasma sTREM-1 level may be elevated in UTI and may therefore serve as a useful predictive tool for the diagnosis of UTI.
dc.identifier.doi10.1055/s-0041-1724024
dc.identifier.endpage133
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85101864278
dc.identifier.scopusqualityQ4
dc.identifier.startpage129
dc.identifier.urihttps://doi.org/10.1055/s-0041-1724024
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24519
dc.identifier.volume16
dc.identifier.wosWOS:000621594600004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofJournal of Pediatric Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjecturinary tract infections; biomarker; myeloid cells-1
dc.titleDiagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Children with Urinary Tract Infections
dc.typeArticle

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