Synthesis and drug delivery performance of gelatin-decorated magnetic graphene oxide nanoplatform

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dc.contributor.authorIşıklan, Nuran
dc.contributor.authorHussien, Nizamudin Awel
dc.contributor.authorTürk, Mustafa
dc.date.accessioned2025-01-21T16:44:48Z
dc.date.available2025-01-21T16:44:48Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn the present study, we have designed and developed gelatin-decorated magnetic graphene oxide nanoplatform (MGO@GEL) for photothermal therapy and paclitaxel delivery. The surface morphology, chemical structure, magnetic property, and thermal stability of the MGO@GEL nanosheets were investigated using TEM, AFM, FTIR, XRD, BET, VSM, and TGA methods. Paclitaxel (PAC) as a chemotherapy drug, release behavior was performed at two pH levels and showed strong pH dependence. The anticancer efficiency and biocompatibility of the nanosheets were achieved by MTT analysis using MCF-7 cancer cells with and without 808 NIR laser and L-929 fibroblast cells. Furthermore, the pH-sensitive release behavior of the nanosheets demonstrated higher PAC release at pH 5.5 than at pH 7.4. Moreover, cytotoxicity analysis illustrated the MGO@GEL nanosheets are biocompatible while MGO@GEL@PAC nanosheets exhibited high toxicity to kill MCF-7 cells, especially with NIR laser. Based on the obtained results, the developed multifunctional nanostructures may be a promising candidate for chemo-photothermal therapy and drug delivery.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale University [2017/055]
dc.description.sponsorshipThe authors are thankful to the Scientific Research Projects Coordination Unit of Kirikkale University [Project number: 2017/055, 2017] for their financial support.
dc.identifier.doi10.1016/j.colsurfa.2021.126256
dc.identifier.issn0927-7757
dc.identifier.issn1873-4359
dc.identifier.scopus2-s2.0-85101343224
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.colsurfa.2021.126256
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25514
dc.identifier.volume616
dc.identifier.wosWOS:000635442100004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces A-Physicochemical and Engineering Aspects
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectNano platform; Graphene oxide; Gelatin; Iron oxide; Photothermal therapy; Drug delivery
dc.titleSynthesis and drug delivery performance of gelatin-decorated magnetic graphene oxide nanoplatform
dc.typeArticle

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