p(thyme oil) and p(clove oil) organo-particles with biocompatible, anticancer, antioxidant, and antibacterial properties against Capan-1 and L-929 cells

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dc.authoridAktas, Nahit/0000-0001-9341-607X
dc.authoridAlpaslan, Duygu/0000-0002-6007-3397
dc.contributor.authorAlpaslan, Duygu
dc.contributor.authorDudu, Tuba Ersen
dc.contributor.authorBozer, Busra Moran
dc.contributor.authorAktas, Nahit
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2025-01-21T16:43:17Z
dc.date.available2025-01-21T16:43:17Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe synthesis of p(ClO) and p(TO) organo-particles from clove oil and thyme oil is the first in the literature. The particles were tested against the L-929 cell line for cell viability/cytotoxicity. The anticancer activity was studied against the Capan-1 pancreatic cancer cell line. p(ClO) and p(TO) organo-particles were featured by thermogravimetry (TGA), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), particle size (DLS), and particle charge (zeta potential, Zeta) analyses. Antioxidant, biocompatible, antimicrobial, and in vitro cytotoxicity specialties were investigated. p(ClO) and p(TO) organo-particles were found to be effective on the L-929 fibroblast cell line and Capan-1 pancreatic cancer cell line in research on Capan-1 and L-929 cell lines. Additionally, it was shown that large dosages of p(ClO) organo-particles were not hazardous to L-929 cell lines. A difference was found between the rates of cell viability and apoptosis and necrosis when the MTT study findings of p(ClO) and p(TO) organo-particles were studied in Capan-1 cell line. The p(TO) organo-particle had the highest % apoptosis rate. At the 100 g mL(-1) concentration, the fibroblast cell viability of p(ClO) and p(TO) organo-particles was 176.46% and 107.78%, respectively. The IC50 value derived for the decrease in viability was determined as (2.22 mg mL(-1)) and it was calculated that it would kill the pancreatic cancer cells by 50% when doxorubicin and p(ClO) were administered combined.
dc.identifier.doi10.1002/cjce.25061
dc.identifier.endpage87
dc.identifier.issn0008-4034
dc.identifier.issn1939-019X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85168162973
dc.identifier.scopusqualityQ2
dc.identifier.startpage76
dc.identifier.urihttps://doi.org/10.1002/cjce.25061
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25234
dc.identifier.volume102
dc.identifier.wosWOS:001051765100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofCanadian Journal of Chemical Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectcell; clove oil; organo-particle; thymol oil
dc.titlep(thyme oil) and p(clove oil) organo-particles with biocompatible, anticancer, antioxidant, and antibacterial properties against Capan-1 and L-929 cells
dc.typeArticle

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