Şap hastalıklı danalarda plazma monosit kemoatraktan protein-1 ve İnterlökin-1α düzeylerinin ve bu düzeylerle kan lenfosit ve monosit sayıları arasındaki ilişkilerin incelenmesi
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Tarih
2006
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info:eu-repo/semantics/openAccess
Özet
Bu çalışmada, şap hastalıklı danalarda plazma monosit kemoatraktan protein-1 (MCP-1) ve interlökin 1-a (İL-la) düzeylerinin ve bu düzeyler ile kandaki lenfosit ve monosit sayıları arasındaki ilişkilerin incelenmesi amaçlandı. Bu amaçla, 1-1.5 yaşlarında 16 adet şap hastalıklı ve 11 adet sağlıklı dana kullanıldı. Şap hastalıklı danalarda plazma MCP-1 ve İL-la düzeyleri sağlıklı gruba göre önemli derecede yükselmiş bulundu (p0.001). Şap hastalıklı danalarda plazma MCP-1 ve IL-la düzeyleri ile kandaki lenfosit ve monosit sayıları arasında önemli derecede ilişki olduğu belirlendi (p0.01). Kandaki lenfosit ve monosit artışına paralel olarak plazma MCP-1 ve ILI-a düzeylerinin de önemli derecede artmış olması, MCP-1 ve IL-la'nın şap hastalığının patogenezinde rol aldığını düşündürmektedir.
In this study, detection of plasma monocyte chemoattractant protein-1 (MCP-1) and interleukin-1 (IL-la) levels and correlations between these levels and blood lymphocyte and monocyte numbers was aimed. 1-1.5 years old 16 calves with foot and mouth disease and 11 calves with healthy were used in study. The levels of MCP-1 and IL-la in plasma were found to be significantly increased in calves with foot and mouth disease compared to healthy group (p<0.001). Between the plasma MCP-1 and IL-la levels and blood lymphocyte and monocyte numbers were determined to be significantly correlated (p<0.01) in calves with foot and mouth disease. In the present study, the number of blood lymphocytes and monocytes was positively correlated with plasma MCP-1 and IL-la concentrations that suggests MCP-1 and IL-la are involved in etiopathogenesis of foot and mouth disease.
In this study, detection of plasma monocyte chemoattractant protein-1 (MCP-1) and interleukin-1 (IL-la) levels and correlations between these levels and blood lymphocyte and monocyte numbers was aimed. 1-1.5 years old 16 calves with foot and mouth disease and 11 calves with healthy were used in study. The levels of MCP-1 and IL-la in plasma were found to be significantly increased in calves with foot and mouth disease compared to healthy group (p<0.001). Between the plasma MCP-1 and IL-la levels and blood lymphocyte and monocyte numbers were determined to be significantly correlated (p<0.01) in calves with foot and mouth disease. In the present study, the number of blood lymphocytes and monocytes was positively correlated with plasma MCP-1 and IL-la concentrations that suggests MCP-1 and IL-la are involved in etiopathogenesis of foot and mouth disease.
Açıklama
Anahtar Kelimeler
Veterinerlik
Kaynak
Ankara Üniversitesi Veteriner Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
53
Sayı
2
