Evaluation of Anticholinergic, Antidiabetic and Antioxidant Activity of Astragalus dumanii, an Endemic Plant

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dc.authoridGökalp, Faik/0000-0003-4363-3839
dc.authoridKoçyiğit, Ümit Muhammet/0000-0001-8710-2912
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authoridGülçin, İlhami/0000-0001-5993-1668
dc.authoridEruygur, Nuraniye/0000-0002-4674-7009
dc.authoridTekin, Mehmet/0000-0002-1157-1314
dc.authoridAtaş, Mehmet/0000-0002-9425-0080
dc.contributor.authorKoçyiğit, Ümit Muhammet
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorAtaş, Mehmet
dc.contributor.authorTekin, Mehmet
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGökalp, Faik
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2025-01-21T16:33:37Z
dc.date.available2025-01-21T16:33:37Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe research was conducted to separately evaluate and detect the possible in vitro antioxidant, antimicrobial activity of ethanol extracts prepared from aerial parts and roots of Astragalus dumanii and anti-cholinesterase and alpha-glucosidase inhibitory activity from only aerial parts of its The antioxidant capacity was tested by scavenging of DPPH and ABTS free radicals. Compared with the standard antioxidant compound gallic acid; Root and aerial part extract showed lower DPPH radical scavenging activity, however aerial part extract demonstrated higher ABTS radical scavenging activity. The phenolic contents were detected as 5.31 +/- 0.03 and 13.23 +/- 0.05 mg gallic acid equivalent g-1 extract, flavonoid contents were found as 8.26 +/- 0.004 and 7.93 +/- 0.005 mg Qercetin equivalent g-1 extract. In addition, the effects of the extracts obtained from aerial parts of the plant on acetylcholinesterase, butyrylcholinesterase and a-glycosidase enzymes were investigated in vitro and IC50 values were obtained as 1.47, 0.83 and 0.48 mu g mL-1, respectively. When these values were compared with standard substances, it was seen that Astragalus dumanii could be a good enzyme inhibitory agent. Antimicrobial activity of the plant extracts were determined using the microdilution method and the extracts was not observed to have any antimicrobial activities..
dc.identifier.doi10.18016/ksutarimdoga.vi.895616
dc.identifier.endpage10
dc.identifier.issn2619-9149
dc.identifier.startpage1
dc.identifier.trdizinid1171146
dc.identifier.urihttps://doi.org/10.18016/ksutarimdoga.vi.895616
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1171146
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23813
dc.identifier.volume25
dc.identifier.wosWOS:000899419700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKahramanmaras Sutcu Imam Univ Rektorlugu
dc.relation.ispartofKsu Tarim Ve Doga Dergisi-Ksu Journal of Agriculture and Nature
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAstragalus dumanii; Antioxidant; Antidiabetic; Acetylcholinesterase; Butyrylcholinesterase
dc.titleEvaluation of Anticholinergic, Antidiabetic and Antioxidant Activity of Astragalus dumanii, an Endemic Plant
dc.typeArticle

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