Is tannic acid a promising option in local treatment of nasal diseases?

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dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.contributor.authorAlqunaee, M.
dc.contributor.authorMuluk, N. Bayar
dc.contributor.authorCosan, D. Turgut
dc.contributor.authorCingi, C.
dc.date.accessioned2025-01-21T16:42:15Z
dc.date.available2025-01-21T16:42:15Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: We investigated the effects of tannic acid on viability and proliferation of nasal cells after topical application. It was also evaluated whether tannic acid served as an alternative treatment agent. MATERIALS AND METHODS: Collected primary nasal epithelium from healthy people who had undergone septoplasty operations were incubated in cell culture. Following the implementation of 2.5 mu M tannic acid in cultured cells, both the number of total cells and their viability were measured using the trypan blue assay, while proliferation was assessed through the XTT method. The XTT method, which involves using 2,3-bis-(2-methoxy-4-nitro-5-sulphophenyl)-2H-tetrazolium-5-carboxanilide, is a reliable means of determining cellular toxicity. RESULTS: XTT experiment results showed that there was no harm was detected to nasal cells after tannic acid's topical implementation. There were no significant changes in cell proliferation; moreover, no matter what the doses were. Additionally, no cytotoxic effects were detected on nasal cells primary culture at the end of the 24 hours of implementation. There was no side effect of it, either. CONCLUSIONS: According to the research, the application of tannic acid topically did not result in any harmful effects on the nasal cell culture. Tannic acid's potential anti-inflammatory properties and its ability to decrease Th2-related cytokines suggest that it may be beneficial for patients with rhinosinusitis or allergic rhinitis, pending confirmation through clinical trials. Additionally, if clinical trials confirm its effectiveness, tannic acid may be useful in healing wounds for patients undergoing septorhinoplasty.
dc.identifier.endpage82
dc.identifier.issn1128-3602
dc.identifier.pmid37350692
dc.identifier.startpage76
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25029
dc.identifier.volume27
dc.identifier.wosWOS:001011478000008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectTannic acid; Nasal cells; Cytotoxic effect; Cell viability
dc.titleIs tannic acid a promising option in local treatment of nasal diseases?
dc.typeArticle

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