Genetic variations and antibiotic resistance patterns of Staphylococcus aureus isolates from human and bovine

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dc.contributor.authorUnal, N.
dc.contributor.authorIstanbulluoglu, E.
dc.contributor.authorGur, D.
dc.contributor.authorUnal, S.
dc.contributor.authorBulun, H.
dc.date.accessioned2020-06-25T17:48:15Z
dc.date.available2020-06-25T17:48:15Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionUNAL, SERHAT/0000-0003-1184-4711
dc.description.abstractThe study was performed to estimate the genetic relationship among 96 Staphylococcus aureus isolates obtained from human and bovine origins by pulsed-field gel electrophoresis (PFGE) and to investigate resistance profiles of the isolates to 11 antimicrobial agents by the E-test. Thirteen of the human isolates (26%) were resistant to methicillin (MRSA), although all the bovine isolates were Susceptible. In 96 isolates, 45 distinct PFGE types were identified. The results of PFGE were assigned to 18 lineage groups designated A through S based on estimates of genetic relationship. Cluster analysis showed that bacterial genotypes were associated with a single host species. The genotypes corresponding to strains of human origin were more heterogenous. Seventy six percent of the bovine isolates and 34% of the human isolates were assigned to lineage group S and K respectively. Approximately 70% of MRSA strains were included in lineage group K and the comparison of MSSA and MRSA strains showed that the strains were not closely linked. With the exception of MRSA strains, high degree of correlation wits not observed between antimicrobial resistance patterns and the pulsotypes of the isolates. While resistance to penicilin was 100% in human and 80.4% in bovine isolates, it was 48% and 4.3% for erythromycin in human and bovine isolates, respectively. In addition 84.6% of MRSA strains were also resistant to 8 different antimicrobials. It was concluded that the relationship between human and bovine S. aureus isolates were not detected and the number of pulsotype responsible for cow mastitis was limited. MRSA in S. aureus isolates from bovine origin were not ascertained while the rates of resistance to antimicrobial drugs were lower in bovine isolates than those of human isolates.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage468en_US
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-72849145763
dc.identifier.scopusqualityN/A
dc.identifier.startpage463en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4375
dc.identifier.volume160en_US
dc.identifier.wosWOS:000272099400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaire
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectantimicrobial susceptibilityen_US
dc.subjectminimum inhibitory concentrationen_US
dc.subjectpulsed-field gel electrophoresisen_US
dc.subjectbovineen_US
dc.subjecthumanen_US
dc.titleGenetic variations and antibiotic resistance patterns of Staphylococcus aureus isolates from human and bovineen_US
dc.typeArticle

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