Potential protective effect of resveratrol on acoustic trauma: electron microscopy study

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dc.contributor.authorHanci, D.
dc.contributor.authorUlusoy, S.
dc.contributor.authorAcar, M.
dc.contributor.authorBurukoglu, D.
dc.contributor.authorKutlu, H. M.
dc.contributor.authorMuluk, N. Bayar
dc.contributor.authorCingi, C.
dc.date.accessioned2020-06-25T18:16:22Z
dc.date.available2020-06-25T18:16:22Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: To investigate the potential preventive effect of resveratrol in rats exposed to acoustic trauma (AT). MATERIALS AND METHODS: In this experimental study, Wistar albino rats were divided into three groups: Group 1 (Control, n = 6), Group 2 (AT, n = 6), and Group 3 (resveratrol + AT). The rats in Group 2 were exposed to AT. The rats in Group 3 received resveratrol (300 mg/kg/day) via gavage for 7 days. On day 7, the rats were exposed to AT 10 min following resveratrol treatment. Histological sections of the cochleae were examined using light microscopy, transmission (TEM), and scanning electron microscopy (SEM). RESULTS: The cochlear hair cells, stereocilia, and Deiters' cells of the control group appeared normal in all microscopic evaluations. In Group 2, light microscopy revealed predominantly inner hair cell loss, although the outer hair cells were affected. TEM and SEM examination showed severe loss of stereocilia and SEM revealed stereocilia arranged in an asymmetric array. The cochlear structure in Group 3 appeared well preserved under the light microscope, and although TEM and SEM revealed stereocilia loss, the hair cells and stereocilia appeared near normal compared with those of Group 2. CONCLUSIONS: Resveratrol may have a protective effect against AT damage in the cochlea, most likely through its antioxidant activity. Our results may be useful for studies in humans exposed to AT and noise-induced hearing loss related to chronic exposure to occupational noise.en_US
dc.description.sponsorshipContinuous Education and Scientific Research Associationen_US
dc.description.sponsorship"With the exception of data collection, the preparation of this paper, including design and planning, was supported by the Continuous Education and Scientific Research Association." Only scientific support was provided; no grant or funding was received.en_US
dc.identifier.citationHanci, D., Ulusoy, S., Acar, M., Burukoglu, D., Kutlu, H. M., Bayar Muluk, N., & Cingi, C. (2016). Potential protective effect of resveratrol on acoustic trauma: electron microscopy study. European review for medical and pharmacological sciences, 20(16), 3469–3475.en_US
dc.identifier.endpage3475en_US
dc.identifier.issn1128-3602
dc.identifier.issue16en_US
dc.identifier.pmid27608909
dc.identifier.startpage3469en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6504
dc.identifier.volume20en_US
dc.identifier.wosWOS:000384168600022
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectResveratrolen_US
dc.subjectAcoustic traumaen_US
dc.subjectLight microscopyen_US
dc.subjectTransmission electron microscopyen_US
dc.subjectScanning electron microscopyen_US
dc.titlePotential protective effect of resveratrol on acoustic trauma: electron microscopy studyen_US
dc.typeArticle

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