Synthesis, characterization and wound healing ability of PET based nanofiber dressing material coated with silk sericin capped-silver nanoparticles

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dc.contributor.authorGün Gök Z.
dc.contributor.authorYiğitoğlu M.
dc.contributor.authorVargel İ.
dc.contributor.authorŞahin Y.
dc.contributor.authorAlçığır M.E.
dc.date.accessioned2021-01-14T18:11:13Z
dc.date.available2021-01-14T18:11:13Z
dc.date.issued2021
dc.departmentKKÜ
dc.description.abstractIn this study, silver nanoparticles coated with sericin (S-AgNPs) were adsorbed on poly (ethylene terephthalate)-g-poly(hydroxyethylmethacrylate) (PET-g-HEMA) nanofibers and the use of the obtained material as wound dressing was investigated. PET fibers were firstly grafted with HEMA for varying hydrophobic nature of PET. A wound dressing material was obtained from polymer solution of this copolymer with electrospinning under certain conditions. Then, negatively charged S-AgNPs were adsorbed on the surface of the nanofiber membranes. Scanning electron microscope (SEM), UV–Vis, X-ray fluorescence (XRF), thermal, mechanical, antibacterial and cytotoxicity analyzes of the modified membranes have been examined. It was found that the modified nanofibers with S-AgNPs had antimicrobial effects on gram positive and gram negative bacteria. The viability rates of the cells incubated with the modified material extract did not decrease below 70% after 1 and 3 days incubation in MTT test. In-vivo studies aimed at evaluating the performance of modified nanofiber surface were performed using Sprague-Dawley male rats. The healing process of deep burn wounds created in rats with different materials was monitored during the 21 days and it was found that the produced nanofibers was more effective in wound healing than the control group and had a healing rate close to a commercially used cover material. © 2020 Elsevier B.V.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK: 218S449en_US
dc.description.sponsorshipThe present work was financially promoted by the Scientific and Technological Research Council of Turkey (Project Number: 218S449 ).en_US
dc.identifier.doi10.1016/j.matchemphys.2020.124043
dc.identifier.issn0254-0584
dc.identifier.scopus2-s2.0-85096408786
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.matchemphys.2020.124043
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12918
dc.identifier.volume259en_US
dc.identifier.wosWOS:000615730500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Ltden_US
dc.relation.ispartofMaterials Chemistry and Physics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolyethylene terephthalateen_US
dc.subjectSilver nanoparticleen_US
dc.subjectSurface modificationen_US
dc.subjectWound dressingen_US
dc.titleSynthesis, characterization and wound healing ability of PET based nanofiber dressing material coated with silk sericin capped-silver nanoparticlesen_US
dc.typeArticle

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