Hippocampal ZnT3 (SLC30A3) Levels Reflect Hippocampal Tissue Damage in Chronic Exercising Diabetic Rats

Basit Öğe Kaydı
dc.authoridBaltacı, Saltuk Buğra/0000-0002-9752-7508
dc.authoridMenevşe, Esma/0000-0002-5477-5667
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.contributor.authorYaslı, Mehmet
dc.contributor.authorBaltacı, Saltuk Buğra
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorMenevşe, Esma
dc.contributor.authorÜnal, Ömer
dc.date.accessioned2025-01-21T16:33:47Z
dc.date.available2025-01-21T16:33:47Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: In this study, it was investigated how chronic exercise affects hippocampus tissue damage and ZnT3 levels in diabetic rats. Methods: The 40 adult rats were used in the study were divided into 4 equal groups: Control (G1), Exercise Control (G2), Diabetes (G3), Diabetes+Exercise (G4). Diabetes was induced in animals in G3 and G4 by injecting intraperitoneal streptozotocin (STZ) twice, 24 hours apart. The animals in G2 and G4 were runed on the rat treadmill for 45 minutes daily for 4 weeks. MDA (spectrophotometric method) and ZnT3 (ELISA method) levels were determined in hippocampus tissue samples obtained from animals sacrificed at the end of the experimental procedures.Results: In the current study, the highest MDA and lowest ZnT3 levels in the hippocampus tissue were obtained in the diabetes group (G3) (P<0.05). Chronic exercise prevented increased hippocampal tissue damage in diabetic rats and reversed decreased ZnT3 levels (P<0.05). Conclusion: The results of our study showed that 4 weeks of chronic exercise could be prevent increased tissue damage in the hippocampus tissue of diabetic rats and ameliorate the decreased ZnT3 levels. The data obtained in this study indicate that ZnT3 levels in diabetic rats may be an indicator of hippocampal tissue damage.
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University [18202032]
dc.description.sponsorshipFunding: This study was supported by the Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK; project no. 18202032) .
dc.identifier.doi10.58600/eurjther1874
dc.identifier.endpage28
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue1
dc.identifier.startpage21
dc.identifier.trdizinid1226109
dc.identifier.urihttps://doi.org/10.58600/eurjther1874
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1226109
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23856
dc.identifier.volume30
dc.identifier.wosWOS:001146320000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherPera Yayincilik Hizmetleri
dc.relation.ispartofEuropean Journal of Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectChronic exercise; diabetes; MDA; hippocampus; ZnT3
dc.titleHippocampal ZnT3 (SLC30A3) Levels Reflect Hippocampal Tissue Damage in Chronic Exercising Diabetic Rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin/Full Text
Boyut:
452.34 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu