Analysis of MMP-7 and TIMP-2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case-control study

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dc.contributor.authorAlp, Ebru
dc.contributor.authorYilmaz, Akin
dc.contributor.authorTulmac, Murat
dc.contributor.authorDikmen, Atiye Ugras
dc.contributor.authorCengel, Atiye
dc.contributor.authorYalcin, Ridvan
dc.contributor.authorMenevse, Emine Sevda
dc.date.accessioned2020-06-25T18:23:11Z
dc.date.available2020-06-25T18:23:11Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionYILMAZ, AKIN/0000-0002-4368-0777
dc.description.abstractMatrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP) have a significant role in tissue remodeling related to cardiac function. In earlier studies, MMP-7A-181G (rs11568818), C-153T (rs11568819), C-115T (rs17886546), and TIMP-2 G-418-C (rs8179090) polymorphisms have been studied in various diseases. However, association between coronary artery disease (CAD) and these polymorphisms has been poorly studied. The goal of this study is to investigate the association of CAD and myocardial infarction (MI) with MMP-7 or TIMP-2 polymorphisms. This study included 122 CAD patients and 132 control individuals. DNA was extracted from whole blood. Polymerase chain reaction-restriction fragment length polymorphism and automated direct sequencing method were used for genotyping of these polymorphisms. No significant differences were found between MMP-7 A-181G, C-115T, and TIMP-2 G-418C polymorphism and CAD or MI in a Turkish population. Despite the fact that the genotypes of MMP-7C-153T polymorphism had no significant differences among MI and control groups, allele frequencies of C-153T polymorphism were significantly different between the two groups. Our study is the first report to clarify the appreciable relationship between MMP-7 C-153T polymorphism and MI development in CAD patients. However, these findings also need to be confirmed in other populations so we can improve our knowledge about the genetic factors affecting the development of CAD. Copyright (C) 2017, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.description.sponsorshipGazi University Research FundGazi University [11/2004-84]en_US
dc.description.sponsorshipThe authors are very thankful to all volunteers who participated in this study. We are also thankful to Hacer Ilke Onen and Mehmet Galip Icduygu for valuable contribution. This study was partially supported by Gazi University Research Fund as a project with code number 11/2004-84.en_US
dc.identifier.citationAlp, E., Yilmaz, A., Tulmac, M., Ugras Dikmen, A., Cengel, A., Yalcin, R., & Menevse, E. S. (2017). Analysis of MMP-7 and TIMP-2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case-control study. The Kaohsiung journal of medical sciences, 33(2), 78–85.en_US
dc.identifier.doi10.1016/j.kjms.2016.12.002
dc.identifier.endpage85en_US
dc.identifier.issn1607-551X
dc.identifier.issue2en_US
dc.identifier.pmid28137415
dc.identifier.scopus2-s2.0-85009728719
dc.identifier.scopusqualityQ1
dc.identifier.startpage78en_US
dc.identifier.urihttps://doi.org/10.1016/j.kjms.2016.12.002
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7034
dc.identifier.volume33en_US
dc.identifier.wosWOS:000394727100004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofKaohsiung Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectMMP-7en_US
dc.subjectMyocardial infarctionen_US
dc.subjectPolymorphismen_US
dc.subjectTIMP-2en_US
dc.titleAnalysis of MMP-7 and TIMP-2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case-control studyen_US
dc.typeArticle

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