Comparison of soluble suppression of tumorigenicity 2 and brachial hemodynamic parameters between dialysis modalities in patients with end-stage kidney disease

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dc.authoridYETER, hasan haci/0000-0002-5787-1048
dc.contributor.authorYeter, Haci Hasan
dc.contributor.authorKaracalik, Ceren
dc.contributor.authorEraslan, Esra
dc.contributor.authorDurantas, Halil
dc.contributor.authorAkcay, Omer Faruk
dc.contributor.authorDerici, Kursat
dc.contributor.authorDerici, Ulver
dc.date.accessioned2025-01-21T16:36:50Z
dc.date.available2025-01-21T16:36:50Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose Major cardiovascular events (MACE) are the leading cause of mortality in patients with chronic kidney disease. Although hemodialysis (HD) and peritoneal dialysis (PD) are comparable in survival, patients with HD have a significantly higher risk of developing MACE. Soluble suppression of tumorigenicity 2 (sST2) is a cardiac biomarker, that does not vary with age, gender, and kidney function. This study aimed to compare arterial stiffness, fluid status, and sST2 levels, between patients with PD and those with in-center HD.Methods This was a cross-sectional study, which was conducted with 36 PD patients, 36 HD patients, and 36 age, and gender-matched healthy controls. We used noninvasive methods for the assessment of arterial stiffness and fluid status.Results The patients with PD overhydrated compared to HD patients and healthy control (p < 0.001, and p = 0.05, respectively). Patients with PD had higher central systolic blood pressure and central pulse pressure than patients with HD and the control group (p = 0.004, and p = 0.01; p < 0.001, and p = 0.004, respectively). HD patients had a significantly higher level of plasma sST2 level compared to PD patients and the control group (p = 0.03, and p = 0.005). HD as maintenance dialysis modality and dialysis vintage was associated with higher plasma sST2 concentration, and having a residual renal function in dialysis patients was related to the lower plasma sST2 concentration.Conclusion PD is associated with better sST2 levels even though higher volume load than HD. In addition, the loss of RRF may be the most important factor related to increased sST2.
dc.identifier.doi10.1007/s11255-022-03443-7
dc.identifier.endpage1342
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue5
dc.identifier.pmid36528841
dc.identifier.scopus2-s2.0-85144226017
dc.identifier.scopusqualityQ2
dc.identifier.startpage1335
dc.identifier.urihttps://doi.org/10.1007/s11255-022-03443-7
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24393
dc.identifier.volume55
dc.identifier.wosWOS:000900202600002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectBioimpedance spectroscopy; Pulse wave velocity; Soluble suppression of tumorigenicity 2; Peritoneal dialysis; Hemodialysis
dc.titleComparison of soluble suppression of tumorigenicity 2 and brachial hemodynamic parameters between dialysis modalities in patients with end-stage kidney disease
dc.typeArticle

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