The effect of krill oil on Wnt/ß-catenin signaling pathway in acetaminophen-induced acute liver injury in mice

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dc.contributor.authorŞahin, Yaşar
dc.contributor.authorDevrim, Alparslan Kadir
dc.contributor.authorAlçiğir, Mehmet Eray
dc.contributor.authorŞenol, Ali
dc.contributor.authorEkici, Hüsamettin
dc.contributor.authorDevrim, Tuba
dc.contributor.authorSudağidan, Mert
dc.date.accessioned2025-01-21T16:28:39Z
dc.date.available2025-01-21T16:28:39Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: This study investigated the effect of krill oil (KO) on liver damage caused by acetaminophen (APAP). Methods: In the present study, the control and APAP groups were given distilled water by gavage for 14 days. In addition, the KO and APAP+KO groups were given 500 mg/kg krill oil by gavage for 14 days. At the end of 14 days, 0.9 % sodium chloride solution (saline solution) administration was applied intraperitoneally to the control and KO groups. Meanwhile, 220 mg/kg acetaminophen was administered to the APAP and APAP+KO groups. While some biochemical parameters in plasma were examined, some oxidative stress parameters in plasma and liver tissue were evaluated. Apoptotic and inflammatory responses of some primer sequences determined by quantitative Real-Time PCR (qPCR) in liver tissue. After histopathological examination of liver tissue, immunohistochemical analysis was performed with Wnt inhibitory factor-1 (Wif-1), beta-catenin (ß-Catenin), and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Results: The Wif-1 positivity in hepatocytes increased significantly in the APAP group (5.29 ± 0.71) compared to the control (1.14 ±0.51), and KO (2.14 ± 0.55) groups (p<0.001). The 8-OHdG positivity in hepatocytes increased significantly in the APAP group (19.57 ± 0.58) compared to the control (0.43 ± 0.20), KO (3.57 ± 0.48), and APAP+KO (4.00 ± 2.53) groups (p<0.001).Conclusions: As a result, krill oil could be used as a nutritional supplement to protect the liver against acetaminophen-induced liver injury. © 2023 De Gruyter. All rights reserved.
dc.identifier.doi10.1515/tjb-2022-0289
dc.identifier.endpage271
dc.identifier.issn0250-4685
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85170435725
dc.identifier.scopusqualityQ3
dc.identifier.startpage264
dc.identifier.trdizinid1251874
dc.identifier.urihttps://doi.org/10.1515/tjb-2022-0289
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1251874
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23607
dc.identifier.volume48
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherDe Gruyter Open Ltd
dc.relation.ispartofTurkish Journal of Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectacetaminophen; acute liver injury; krill oil; oxidative stress; qPCR
dc.titleThe effect of krill oil on Wnt/ß-catenin signaling pathway in acetaminophen-induced acute liver injury in mice
dc.typeArticle

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