Magnesium Sulfate Has Potential Scavenging Effects on Cyclophosphamide-Induced Ovarian Damage in A Rat Model
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: This study proposed to investigate whether magnesium sulfate (MgSO4)could reduce the ovarian damage induced by cyclophosphamide (Cyc). Material and Methods:Thirty female rats were used for this study: Control group (n10)- Only laparotomy; Cyc groupn10)-75 mg/kg Cyc intraperitoneally; and CycMgSO4 group (n10)-75 mg/kg Cyc on day 0 and200 mg/kg MgSO4 on days 1-7 (both intraperitoneally). The extent of histopathological damage andthe number of ovarian follicles were determined. The levels of anti-Mullerian hormone (AMH)were measured in blood samples. Results: Statistically significant differences in the AMH valueswere observed in the control group versus Cyc group and Cyc group versus CycMgSO4 group(p0.05). The levels of AMH were the least in the Cyc group. The total tissue damage in the Cycgroup was significantly higher than that in the control, as well as in the CycMgSO4 group(p0.05). The follicle counts were the least in the Cyc group. Conclusion: Cyc caused ovarian damage and reduced the ovarian reserves. The ovarian reserves in the MgSO4-treated group were better than those in the other groups, and there was least ovarian damage in the MgSO4-treated group.
Açıklama
Anahtar Kelimeler
Kadın Hastalıkları ve Doğum
Kaynak
Journal of Clinical Obstetrics & Gynecology
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
29
Sayı
1
Künye
Yeral, M. İ., Sayan, C. D. (2019). Magnesium Sulfate Has Potential Scavenging Effects on Cyclophosphamide-Induced Ovarian Damage in A Rat Model. Journal of Clinical Obstetrics & Gynecology, 29(1), 24 - 30.
