Magnesium Sulfate Has Potential Scavenging Effects on Cyclophosphamide-Induced Ovarian Damage in A Rat Model

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dc.contributor.authorYeral, Mahmut İlkin
dc.contributor.authorSayan, Cemile Dayangan
dc.date.accessioned2020-06-25T14:47:16Z
dc.date.available2020-06-25T14:47:16Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: This study proposed to investigate whether magnesium sulfate (MgSO4)could reduce the ovarian damage induced by cyclophosphamide (Cyc). Material and Methods:Thirty female rats were used for this study: Control group (n10)- Only laparotomy; Cyc groupn10)-75 mg/kg Cyc intraperitoneally; and CycMgSO4 group (n10)-75 mg/kg Cyc on day 0 and200 mg/kg MgSO4 on days 1-7 (both intraperitoneally). The extent of histopathological damage andthe number of ovarian follicles were determined. The levels of anti-Mullerian hormone (AMH)were measured in blood samples. Results: Statistically significant differences in the AMH valueswere observed in the control group versus Cyc group and Cyc group versus CycMgSO4 group(p0.05). The levels of AMH were the least in the Cyc group. The total tissue damage in the Cycgroup was significantly higher than that in the control, as well as in the CycMgSO4 group(p0.05). The follicle counts were the least in the Cyc group. Conclusion: Cyc caused ovarian damage and reduced the ovarian reserves. The ovarian reserves in the MgSO4-treated group were better than those in the other groups, and there was least ovarian damage in the MgSO4-treated group.en_US
dc.identifier.citationYeral, M. İ., Sayan, C. D. (2019). Magnesium Sulfate Has Potential Scavenging Effects on Cyclophosphamide-Induced Ovarian Damage in A Rat Model. Journal of Clinical Obstetrics & Gynecology, 29(1), 24 - 30.en_US
dc.identifier.doi10.5336/jcog.2019-65377
dc.identifier.endpage30en_US
dc.identifier.issn2619-9467
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85095707269
dc.identifier.scopusqualityQ4
dc.identifier.startpage24en_US
dc.identifier.trdizinid334099
dc.identifier.urihttps://doi.org/10.5336/jcog.2019-65377
dc.identifier.urihttps://app.trdizin.gov.tr/publication/paper/detail/TXpNME1EazVPUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1589
dc.identifier.volume29en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of Clinical Obstetrics & Gynecology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKadın Hastalıkları ve Doğumen_US
dc.titleMagnesium Sulfate Has Potential Scavenging Effects on Cyclophosphamide-Induced Ovarian Damage in A Rat Modelen_US
dc.typeArticle

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