Effects of Coronary Angiography and Femoral Arterial Access on Endothelial Functions

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dc.contributor.authorTulmac, Murat
dc.contributor.authorOzer, Nurtac
dc.contributor.authorSimsek, Vedat
dc.contributor.authorDogru, Mehmet Tolga
dc.contributor.authorEbinc, Haksun
dc.date.accessioned2020-06-25T17:51:37Z
dc.date.available2020-06-25T17:51:37Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Impairment of endothelial function is an independent predictor of coronary events. The aim of this study was to clarify the influence of arterial access and coronary angiography on endothelial function. Methods: Eighteen patients with stable angina pectoris who underwent coronary angiography were included in this study. Brachial artery flow-mediated dilatation of patients was measured before angiography, after femoral arterial sheath insertion, and after coronary angiography. Results: Of 18 patients, 11 had angiographically apparent atherosclerosis. Flow-mediated dilatation after femoral arterial sheath insertion (mean +/- SD, 6.62% +/- 3.87%) was found to be significantly lower than either before (10.62% +/- 5.18%) or after coronary angiography (11.66% +/- 5.30%; P = 0.007 and P = 0.001, respectively). Basal and postangiographic flow-mediated dilatation values were similar. Flow-mediated dilatation significantly decreased after sheath insertion in the group with angiographically normal coronary arteries (14.47% +/- 4.34% vs 5.98 +/- 4.00%, respectively; P = 0.006), whereas the difference was not significant in patients with CAD (8.17% +/- 4.16% vs 7.03% +/- 3.92%, respectively). Conclusions: Coronary angiography did not result in endothelial vasomotor dysfunction. Femoral arterial sheath insertion during coronary angiography was associated with a short-lived endothelial dysfunction. Larger studies are needed to interpret the effect of coronary atherosclerosis on attenuation of endothelial response against arterial wall injury.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage1123en_US
dc.identifier.issn1081-5589
dc.identifier.issue7en_US
dc.identifier.pmid21804404
dc.identifier.scopus2-s2.0-84856724398
dc.identifier.scopusqualityQ2
dc.identifier.startpage1121en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4932
dc.identifier.volume59en_US
dc.identifier.wosWOS:000295117800022
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcoronary angiographyen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectflow-mediated dilatationen_US
dc.subjectfemoral arterial sheath insertionen_US
dc.titleEffects of Coronary Angiography and Femoral Arterial Access on Endothelial Functionsen_US
dc.typeArticle

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