Protective effects of ketoprofen on oxidative stress and histopathological changes in testicular ischemia-reperfusion injury in a rat

Basit Öğe Kaydı
dc.contributor.authorÇakan Murat
dc.contributor.authorÇakan Türkan
dc.contributor.authorAydos Tolga
dc.contributor.authorYilmazer Demet
dc.contributor.authorÖğüş Elmas
dc.contributor.authorKılıç Aytun S.
dc.date.accessioned2020-06-25T15:13:57Z
dc.date.available2020-06-25T15:13:57Z
dc.date.issued2007
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction: Testicular torsion is a common surgical emergency affecting newborns, children and adolescents. A possible cause of testicular injury is ischemia-reperfusion (I/R) injury. In this study we evaluated the effect of ketoprofen, a non-steroidal anti-inflammatory drug, on I/R injury due to testicular torsion-detorsion (T/D). Materials and Methods: Twenty-eight prepubertal male Wistar rats were divided into four groups each containing 7 rats: Group 1, control; Group 2, sham; Group 3, T/D; and Group 4, T/D+ketoprofen. Group 3 and 4 underwent 2 hours of left testicular torsion and 4 hours of detorsion. In Group 4, ketoprofen (5 mg/kg) was administrated intraperitoneally 60 minutes before detorsion. At the end of the study, bilateral orchiectomies were performed for measurement of MDA and NO levels and histopathologic examination. Results: Testicular torsion-detorsion significantly induced oxidative stress and tissue damage in both ipsilateral and contralateral testes. Administration of ketoprofen significantly lowered MDA level and improved histologic parameters of spermatogenesis in both testes. Conclusion: Ketoprofen has a protective effect on testicular ischemia-reperfusion injury due to testicular torsion/detorsion.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage55en_US
dc.identifier.issn13005804
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-34249988544
dc.identifier.scopusqualityN/A
dc.identifier.startpage50en_US
dc.identifier.trdizinid71540
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1980
dc.identifier.volume33en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.relation.ispartofTurk Uroloji Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectKetoprofenen_US
dc.subjectTestisen_US
dc.titleProtective effects of ketoprofen on oxidative stress and histopathological changes in testicular ischemia-reperfusion injury in a raten_US
dc.title.alternativeSıçan Testisindeki İskemi-Reperfüzyon Hasarı Sonucu Oluşan Oksidatif Stres Ve Histopatolojik Değişiklikler Üzerine Ketoprofenin Koruyucu Etkisien_US
dc.typeArticle

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