Decreased plasma nesfatin-1 levels in patients with generalized anxiety disorder

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dc.contributor.authorGunay, Huseyin
dc.contributor.authorTutuncu, Recep
dc.contributor.authorAydin, Suleyman
dc.contributor.authorDag, Ersel
dc.contributor.authorAbasli, Dilek
dc.date.accessioned2020-06-25T17:52:24Z
dc.date.available2020-06-25T17:52:24Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.description.abstractNesfatin-1, a recently discovered satiety molecule, is localized in neurons of the hypothalamus and brain stem and colocalized with stress-related substances. However, the relation between nesfatin-1 and stressor related behaviors like anxiety and/or fear has not yet been investigated in human subjects. In the present study, our aim was to investigate whether there was a relationship between plasma nesfatin-1 levels and generalized anxiety disorder. The study group consisted of 40 patients (BMI, 22.98 +/- 0.56) with generalized anxiety disorder and 34 age-matched healthy male control subjects (23.05 +/- 0.4). Patients fully met the fourth Diagnostic and Statistical Manual of Mental Disorders, text revision. Blood samples for nesfatin-1 were drawn at the end of an overnight fasting period at least 10 h. Plasma nesfatin-1 levels were measured and found significantly lower in anxiety disorder group than in control group (0.35 +/- 0.037 ng/ml vs. 0.63 +/- 0.080 ng/ml, respectively, p < 0.05). Low nesfatin-1 levels may be related with generalized anxiety disorder. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.psyneuen.2012.04.007
dc.identifier.endpage1953en_US
dc.identifier.issn0306-4530
dc.identifier.issue12en_US
dc.identifier.pmid22595767
dc.identifier.scopus2-s2.0-84869866502
dc.identifier.scopusqualityQ1
dc.identifier.startpage1949en_US
dc.identifier.urihttps://doi.org/10.1016/j.psyneuen.2012.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5151
dc.identifier.volume37en_US
dc.identifier.wosWOS:000312511000006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPsychoneuroendocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneralized anxiety disorderen_US
dc.subjectPlasma nesfatin-1en_US
dc.subjectSatietyen_US
dc.titleDecreased plasma nesfatin-1 levels in patients with generalized anxiety disorderen_US
dc.typeArticle

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