The effects of propofol and memantine on erythrocyte deformability

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dc.contributor.authorUnal, Y.
dc.contributor.authorComu, F. M.
dc.contributor.authorEmik, U.
dc.contributor.authorAlkan, M.
dc.contributor.authorPampal, H. K.
dc.contributor.authorArslan, M.
dc.date.accessioned2020-06-25T18:12:27Z
dc.date.available2020-06-25T18:12:27Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063; PAMPAL, HASAN KUTLUK/0000-0003-4664-391X
dc.description.abstractObjective: Propofol is an intravenous general anesthetic with a primary hypnotic effect. Memantine is an NMDA receptor antagonist that has been shown to reverse changes in memory and synaptic plasticity in animal models. This study aims to investigates whether propofol and/or memantine has any effects on erythrocyte deformability. Methods: 24 Wistar albino rats were divided randomly into four groups. Group P received 150 mg.kg(-1) propofol intraperitoneally (ip); Group M received 1 mg.kg(-1) memantine (ip); Group PM received 1 mg.kg(-1) memantine mg.kg(-1) ip 30 minutes before the administration of 150 mg.kg(-1) propofol; and the control group (Group C) received saline ip. Euthanasia was performed in all rats by using intraabdominal blood uptake. The heparinized whole blood samples were used to prepare erythrocyte suspensions, from which erythrocyte suspensions were formed with a PBS buffer solution containing 5 % htc, and the deformability parameters were measured. Results: Erythrocyte deformability was significantly higher in Groups P, M and PM when compared to the Group C(p = 0.007 and p = 0.001, p<0.0001, respectively); while the erythrocyte deformability indices were similar in groups P, M and PM. Conclusion: The administration of propofol and memantine altered the erythrocyte deformability in the rats, which may lead to further problems in microcirculation. The administration of memantine to the propofol-treated rats did not alter the erythrocyte deformability; however the early results should be verified through further experimental and clinical studies (Fig. 1, Ref. 23). Text in PDF www.elis.sk.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.4149/BLL_2014_052
dc.identifier.endpage255en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue5en_US
dc.identifier.pmid25174053
dc.identifier.scopus2-s2.0-84901979953
dc.identifier.scopusqualityQ2
dc.identifier.startpage253en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_052
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5926
dc.identifier.volume115en_US
dc.identifier.wosWOS:000336882300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpropofolen_US
dc.subjectmemantineen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectraten_US
dc.titleThe effects of propofol and memantine on erythrocyte deformabilityen_US
dc.typeArticle

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