Diffusion-weighted imaging measurements of central smell regions in COVID-19 patients: insular gyrus, corpus amygdala, and thalamus

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dc.authoridSAYAR, MERVE SEFA/0000-0002-0436-4122
dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.contributor.authorBurulday, V.
dc.contributor.authorMuluk, N. bayar
dc.contributor.authorAkgul, M. H.
dc.contributor.authorSayar, M. S.
dc.date.accessioned2025-01-21T16:37:45Z
dc.date.available2025-01-21T16:37:45Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: The aim of this study was to investigate central smell centers with cranial magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI) in COVID-19.PATIENTS AND METHODS: This retrospec-tive study evaluated cranial MRI images of 54 adults. The experimental group (Group 1), con-sisting of 27 patients with positive COVID-19 real-time Polymerase Chain Reaction (RT-PCR) assays, was compared to the control group (Group 2), comprising 27 healthy con-trols without COVID-19. The apparent diffu-sion coefficient (ADC) values were measured in the corpus amygdala, thalamus, and insular gyrus in both groups. RESULTS: Thalamus ADC values of the COVID-19 group were significantly lower com-pared to the control group bilaterally. Howev-er, no differences were found in the insular gy-rus and corpus amygdala ADC values between the two groups. Positive correlations were ob-served between the insular gyrus and cor-pus amygdala ADC values and the thalamus ADC values. Insular gyrus ADC values (right) were higher in females. Left insular gyrus and corpus amygdala ADC values were higher in COVID-19 patients with smell loss. Right in-sular gyrus and left corpus amygdala ADC values were lower in COVID-19 patients with lymphopenia.CONCLUSIONS: Diffusion restriction in ol-factory areas can be considered an obvious indicator that the COVID-19 virus affects and damages the immune system at the neuro-nal level. Given the urgency and lethality of the current pandemic, acute onset odor loss should be considered a high suspicion-adhe-sive index for patients with SARS-CoV-2 infec-tion. Therefore, the sense of smell should be considered and evaluated simultaneously with other neurological symptoms. DWI should be widely used as an early imaging method for central nervous system (CNS) infections, espe-cially in relation to COVID-19.
dc.identifier.endpage3207
dc.identifier.issn1128-3602
dc.identifier.issue7
dc.identifier.pmid37070924
dc.identifier.scopus2-s2.0-85152971539
dc.identifier.scopusqualityQ2
dc.identifier.startpage3201
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24521
dc.identifier.volume27
dc.identifier.wosWOS:000982646100026
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectCOVID-19; Diffusion-weighted imaging (DWI); Ap-parent diffusion coefficient (ADC); Cranial MRI; Cen-tral smell centers
dc.titleDiffusion-weighted imaging measurements of central smell regions in COVID-19 patients: insular gyrus, corpus amygdala, and thalamus
dc.typeArticle

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