Investigation of the effect of the curcumin component as an alternative to the local treatment of nasal diseases

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dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.contributor.authorCeylan, E.
dc.contributor.authorCosan, D. Turgut
dc.contributor.authorMuluk, N. Bayar
dc.contributor.authorCingi, C.
dc.date.accessioned2025-01-21T16:42:11Z
dc.date.available2025-01-21T16:42:11Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: This study aimed to define the impacts of curcumin on nasal cell viability and proliferation. MATERIALS AND METHODS: Specimens of healthy primary nasal epithelium were collected and incubated in cell culture during septorhinoplasty from people who signed a consent form. After implementing 2.5 mu M curcumin in cultured cells, cell viability was defined via trypan blue assay, and proliferation was defined via the XTT method. The number of total cells, viability, and proliferation was defined. XTT (2,3-bis-(2-methoxy- 4-nitro- 5- sulphophenyl)-2H- tetrazolium-5-carboxanilide) experiments can be used to evaluate cellular toxicity. RESULTS: The results revealed no harm to nasal cells after the topical implementation of curcumin. There was no significant change in the proliferation of the cells related to 24 hours of implementation. There was no adverse effect of using curcumin on the cell viability, either. CONCLUSIONS: No cytotoxic effect on nasal cells has been observed after applying topically implemented curcumin. Curcumin could be used topically for an alternative treatment for allergic rhinitis as it has anti- inflammatory and immune response modulatory effects if clinical trials will confirm experimental data.
dc.identifier.endpage43
dc.identifier.issn1128-3602
dc.identifier.pmid36971219
dc.identifier.scopus2-s2.0-85151043686
dc.identifier.scopusqualityQ2
dc.identifier.startpage39
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25004
dc.identifier.volume27
dc.identifier.wosWOS:000952347300006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectCurcumin; Nasal cells; Potential way of treatment; Cytotoxic effect; Cell viability; Allergic rhinitis.
dc.titleInvestigation of the effect of the curcumin component as an alternative to the local treatment of nasal diseases
dc.typeArticle

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