The effects of oral contraceptives including low-dose estrogen and drospirenone on the concentration of leptin end ghrelin on polycystic ovary syndrome

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dc.contributor.authorSağsöz, Nevin
dc.contributor.authorOrbak, Zerrin
dc.contributor.authorNoyan, Volkan
dc.contributor.authorYücel, Aykan
dc.contributor.authorUçar, Banu
dc.contributor.authorYıldız, Leyla
dc.date.accessioned2020-06-25T17:48:19Z
dc.date.available2020-06-25T17:48:19Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionYucel, Aykan/0000-0002-5888-692X
dc.description.abstractObjective: To evaluate short-term leptin and ghrelin concentrations in women with polycystic ovary syndrome (PCOS) who use low-dose oral contraceptives containing drospirenone. Design: Prospective study. Setting: Department of obstetrics and gynaecology in a university hospital. Patient(s): Twenty women with PCOS were enrolled in the study. Intervention(s): A low-dose oral contraceptive containing ethinyl estradiol and drospirenone was given for three cycles. Main Outcome Measure(s): Serum androstenedione, free T, T, dehydroepiandrosterone sulphate, sex hormone-binding globulin, FSH, LH, E-2, lipid profiles, leptin, and ghrelin levels were measured in each subject. Insulin resistance was estimated by the homeostasis model assessment-insulin resistance (HOMA-IR). Result(s): While leptin concentrations did not change with therapy, ghrelin levels increased statistically. Baseline leptin concentrations were correlated positively with body mass index, waist-to-hip ratio, insulin, and HOMA-IR and negatively with ghrelin. After controlling for body mass index and waist-to-hip ratio in a partial correlation analysis, leptin levels were not correlated with these parameters. Ghrelin was inversely correlated with body mass index, waist-to-hip ratio, insulin, HOMA-IR, and free T. Conclusion(s): In patients with PCOS, an oral contraceptive containing ethinyl estradiol and drospirenone increases ghrelin levels but not leptin levels in a 3-month period. Ghrelin might be related to the metabolic and androgenic changes in patients with PCOS. (Fertil Steril (R) 2009;92:660-6. (C)2009 by American Society for Reproductive Medicine.)en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.fertnstert.2008.07.008
dc.identifier.endpage666en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue2en_US
dc.identifier.pmid18973889
dc.identifier.scopus2-s2.0-67651085354
dc.identifier.scopusqualityQ1
dc.identifier.startpage660en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2008.07.008
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4402
dc.identifier.volume92en_US
dc.identifier.wosWOS:000268915200038
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility And Sterility
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPCOSen_US
dc.subjectleptinen_US
dc.subjectghrelinen_US
dc.subjectdrospirenoneen_US
dc.subjectoral contraceptiveen_US
dc.titleThe effects of oral contraceptives including low-dose estrogen and drospirenone on the concentration of leptin end ghrelin on polycystic ovary syndromeen_US
dc.typeArticle

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