Ghrelin and orexin levels in infertile male: Evaluation of effects on varicocele pathophysiology, relationship seminal and hormonal parameter

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dc.contributor.authorKisa Ü.
dc.contributor.authorMurad Basar M.
dc.contributor.authorSipal T.
dc.contributor.authorCeylan Ö.D.
dc.date.accessioned2021-01-14T18:11:15Z
dc.date.available2021-01-14T18:11:15Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractObjective: The aim of the present study was to investigate serum ghrelin and orexin levels in patients with varicocele and compare these levels with idiopathic infertile male and healthy control cases. Methods: This study enrolled 24 men with varicocele, 24 males having idiopathic infertility, and 21 fertile men as the control group. Hormonal analyses, ghrelin and orexin levels were measured samples. Semen was analyzed after 3 and 5 days of sexual abstinence. Results: Serum ghrelin levels were statistically different among the three groups (p=0.015), and it was due to a statistically lower level in group-1 than the level in the control cases (p=0.012). On the other hand, serum orexin levels were lower than healthy subjects in infertile groups with/without varicocele, but there was no difference (p=0.685) among three groups. Serum ghrelin level showed a negative and significant correlation only with sperm motility (r=-0.646, p=0.022), there was no correlation with other parameters. On the other hand, serum orexin levels did not show a significant correlation with seminal parameters. Conclusion: Both new investigated peptides ghrelin and orexin have regulatory effects on testicular function. However, ghrelin has a more obvious and complex effect on spermatogenesis. Impaired seminal parameters, especially motility was associated with increased serum ghrelin levels in infertile patients, especially with varicocele. © 2020 De Gruyter. All rights reserved.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Management Unit, FÜBAP: 2006/037en_US
dc.description.sponsorshipAcknowledgment: This study was supported by University of Kırıkkale, Scientific Research Projects Unit. Project number (2006/037). Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. Competing interests: None. Çıkar çatışması: Yok.en_US
dc.identifier.doi10.1515/tjb-2020-0084
dc.identifier.endpage882en_US
dc.identifier.issn0250-4685
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85098964852
dc.identifier.scopusqualityQ3
dc.identifier.startpage877en_US
dc.identifier.trdizinid455166
dc.identifier.urihttps://doi.org/10.1515/tjb-2020-0084
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12928
dc.identifier.volume45en_US
dc.identifier.wosWOS:000603517600030
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherDe Gruyter Open Ltden_US
dc.relation.ispartofTurkish Journal of Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGhrelinen_US
dc.subjectInfertilityen_US
dc.subjectOrexinen_US
dc.subjectSemen analysisen_US
dc.subjectVaricoceleen_US
dc.titleGhrelin and orexin levels in infertile male: Evaluation of effects on varicocele pathophysiology, relationship seminal and hormonal parameteren_US
dc.typeArticle

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