Effects of combined aerobic and resistance training on glycemic control, blood pressure, in fl ammation, cardiorespiratory fi tness and quality of life in patients with type 2 diabetes and overweight/obesity: a systematic review and meta-analysis

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dc.authoridMohamed, Mahaneem/0000-0001-9333-1957
dc.authoridGulu, Mehmet/0000-0001-7633-7900
dc.authoridAldayel, Abdulaziz/0000-0002-8499-1117
dc.authoridWADA, YUSUF/0000-0003-0003-9581
dc.contributor.authorAL-Mhanna, Sameer Badri
dc.contributor.authorBatrakoulis, Alexios
dc.contributor.authorGhazali, Wan Syaheedah Wan
dc.contributor.authorMohamed, Mahaneem
dc.contributor.authorAldayel, Abdulaziz
dc.contributor.authorAlhussain, Maha H.
dc.contributor.authorAfolabi, Hafeez Abiola
dc.date.accessioned2025-01-21T16:38:15Z
dc.date.available2025-01-21T16:38:15Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Structured aerobic or resistance training alone seems to be a bene fi cial tool for improving glucose homeostasis, chronic systemic in fl ammation, resting cardiovascular function, and mental health in people with obesity and type 2 diabetes mellitus (T2DM). The aim of the present study was to synthesize the available data on the effectiveness of combined aerobic and resistance training (CART) on glycemic control, blood pressure, in fl ammation, cardiorespiratory fi tness (CRF), and quality of life (QoL) in overweight and obese individuals with T2DM. Methods: A database search was carried out in PubMed, Web of Science, Scopus, Science Direct, Cochrane Library, and Google Scholar from inception up to May 2023. The Cochrane risk of bias tool was used to assess eligible studies, and the GRADE method to evaluate the reliability of evidence. A random-effects model was used, and data were analyzed using standardized mean differences and 95% con fi dence intervals. The study protocol was registered in the International Prospective Register of Systematic Reviews (ID: CRD42022355612). Results: A total of 21,612 studies were retrieved; 20 studies were included, and data were extracted from 1,192 participants (mean age: 57 +/- 7 years) who met the eligibility criteria. CART demonstrated signi fi cant improvements in body mass index, glycated hemoglobin, systolic and diastolic blood pressure, C -reactive protein, tumor necrosis factor -alpha, interleukin-6, CRF, and QoL compared to ST. These fi ndings highlight the signi fi cance of exercise interventions such as CART as essential elements within comprehensive diabetes management strategies, ultimately enhancing overall health outcomes in individuals with T2DM and overweight/ obesity.No differences were found in resting heart rate between CART and ST. An uncertain risk of bias and poor quality of evidence were found among the eligible studies. Conclusion: These outcomes show clear evidence considering the positive role of CART in inducing bene fi cial changes in various cardiometabolic and mental health -related indicators in patients with T2DM and concurrent overweight/obesity. More studies with robust methodological design are warranted to examine the dose -response relationship, training parameters con fi guration, and mechanisms behind these positive adaptations.
dc.description.sponsorshipUniversiti Sains Malaysia [304]
dc.description.sponsorshipFunding This work was supported by the Universiti Sains Malaysia (Grant No. 304.PPSP.6315639) . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.identifier.doi10.7717/peerj.17525
dc.identifier.issn2167-8359
dc.identifier.pmid38887616
dc.identifier.scopus2-s2.0-85196151798
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.7717/peerj.17525
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24612
dc.identifier.volume12
dc.identifier.wosWOS:001250166300003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPeerj Inc
dc.relation.ispartofPeerj
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectExercise; Physical activity; Insulin resistance; Metabolic syndrome; Cardiometabolic health
dc.titleEffects of combined aerobic and resistance training on glycemic control, blood pressure, in fl ammation, cardiorespiratory fi tness and quality of life in patients with type 2 diabetes and overweight/obesity: a systematic review and meta-analysis
dc.typeReview Article

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