Effect of smoking on folic acid and vitamin B-12 after nonsurgical periodontal intervention

dc.contributor.authorErdemir, Ebru Olgun
dc.contributor.authorBergstrom, Jan
dc.date.accessioned2020-06-25T17:43:35Z
dc.date.available2020-06-25T17:43:35Z
dc.date.issued2007
dc.description.abstractAim: The main purpose of this study was to investigate the effect of smoking on the serum levels of folic acid and vitamin B-12 in smokers and nonsmokers with chronic periodontal disease after nonsurgical intervention. Material and Methods: The study base consisted of 45 current smokers and 43 nonsmokers. The clinical parameters included plaque index (PI), gingival index (GI), pocket depth (PD), and clinical attachment level (CAL). Folic acid and vitamin B-12 were determined from peripheral blood samples. Clinical measurements and blood samples were collected at baseline and 1, 3, and 6 months after the intervention. Results: Mean PI was significantly greater in smokers compared with non-smokers throughout the observation period (p < 0.001). During the first month, GI levels significantly decreased in both groups. From months 1 through 6, a significant return towards an increased GI level was observed in smokers (p < 0.001). PD and CAL levels significantly decreased during the first month in both groups. Thereafter, increasing levels of PD and CAL were seen in both groups, although significantly more pronounced in smokers. Throughout the observation period, the mean CAL was significantly greater in smokers relative to nonsmokers (p < 0.001). In smokers, the mean folic acid level gradually and significantly decreased and a slight and significant decrease in mean vitamin B-12 levels was observed in both groups over the entire observation period (p < 0.001). Conclusion: The clinical response to nonsurgical intervention is impaired by smoking and smoking seems to negatively influence the serum level of folic acid following non-surgical intervention.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1600-051X.2007.01154.x
dc.identifier.endpage1081en_US
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.issue12en_US
dc.identifier.pmid17953692
dc.identifier.scopus2-s2.0-36248938685
dc.identifier.scopusqualityQ1
dc.identifier.startpage1074en_US
dc.identifier.urihttps://doi.org10.1111/j.1600-051X.2007.01154.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3808
dc.identifier.volume34en_US
dc.identifier.wosWOS:000251025600009
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Clinical Periodontology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchronic periodontitisen_US
dc.subjectfolic aciden_US
dc.subjectsmokingen_US
dc.subjectvitamin B12en_US
dc.titleEffect of smoking on folic acid and vitamin B-12 after nonsurgical periodontal interventionen_US
dc.typeArticle

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