Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population

Basit Öğe Kaydı
dc.contributor.authorAlp, Ebru
dc.contributor.authorMenevşe, Sevda
dc.contributor.authorTulmaç, Murat
dc.contributor.authorKan, Derya
dc.contributor.authorYalçın, Rıdvan
dc.contributor.authorErkan, Aycan F.
dc.contributor.authorÇengel, Atiye
dc.date.accessioned2020-06-25T17:48:21Z
dc.date.available2020-06-25T17:48:21Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description7th Balkan Meeting on Human Genetics -- AUG 31-SEP 02, 2006 -- MACEDONIA
dc.description.abstractPolymorphic variants of genes encoding proteins involved in vascular remodeling may genetically diverge among different populations and play a role in the susceptibility to the coronary artery disease (CAD). MMP-9-1562 C/T (rs3918242), eNOS T-786C (rs2070744), and Glu298Asp (rs1799983) are among the most studied of these polymorphisms. The aim of this study was to determine the relationship between CAD and these polymorphisms in the Turkish population. The analysis included 146 CAD+ and 122 CAD- individuals. Genomic DNA was isolated from whole blood and genotyping was performed by the PCR-RFLP method. No significant associations were found between -1562 C/T (p=0.557), Glu298Asp (p=0.432), and -786 T/C (p=0.055) polymorphisms and CAD. The distribution of each haplotype also did not differ between CAD+ and the CAD- samples (p>0.05). The present investigation is the first to study an association between -1562 C/T polymorphism and CAD in the Turkish population. In conclusion, no appreciable differences between CAD+ and CAD- samples were found in terms of polymorphisms mentioned above.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1089/dna.2009.0866
dc.identifier.endpage350en_US
dc.identifier.issn1044-5498
dc.identifier.issn1557-7430
dc.identifier.issue7en_US
dc.identifier.pmid19435423
dc.identifier.scopus2-s2.0-67650281498
dc.identifier.scopusqualityQ2
dc.identifier.startpage343en_US
dc.identifier.urihttps://doi.org/10.1089/dna.2009.0866
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4419
dc.identifier.volume28en_US
dc.identifier.wosWOS:000267285500006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofDna And Cell Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleLack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Populationen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population.pdf
Boyut:
209.4 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu