Efficacy and safety of once daily triamcinolone acetonide aqueous nasal spray in adults with non-allergic and allergic rhinitis

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dc.contributor.authorKavut, A. Baccioglu
dc.contributor.authorKalpaklioglu, F.
dc.date.accessioned2020-06-25T18:06:58Z
dc.date.available2020-06-25T18:06:58Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: The efficacy of corticosteroid has not been thoroughly studied in the treatment of non-allergic rhinitis. This study was designed to compare the efficacy of nasal corticosteroid in patients with allergic rhinitis (AR), and non-allergic rhinitis (NAR). Methods: The efficacy of triamcinolone acetonide nasal spray (TANS) on total nasal symptom scores (TNSS), and nasal peak inspiratory flow rate (nPIFR) was studied in a six-week parallel-group trial of NAR (n: 25), and AR (n: 16) patients. Health-related quality of life (HRQoL) and Epworth Sleepiness Scale (ESS) were also analysed. Results: The TNSSs, and symptom scores of conjunctivitis, snoring, and postnasal drainage were significantly improved in both groups, after two and six weeks of treatment. In contrast to AR, patients with NAR had statistically significant improvement in nasal obstruction, and postnasal drainage beginning from two weeks of the treatment. nPIFR slightly increased in both groups. Scores of generic (SF-36), rhinitis specific (MiniRQLQ) and ESS questionnaires generally improved better in AR than MAR. TANS was well-tolerated in AR and NAR groups with minor adverse events including headache, nasal burning, and bitter mouth taste. Conclusions: Our study disproved the idea of ineffectiveness of corticosteroid treatment in NAR, and showed that triamcinolone acetate may be an alternative drug in the treatment of NAR. (C) 2012 SEICAP Published by Elsevier Espana, S.L. All rights reserved.en_US
dc.description.sponsorshipKirikkale University Projects of Scientific ResearchesKirikkale University [2007/4]en_US
dc.description.sponsorshipThis work was supported by a grant from Kirikkale University Projects of Scientific Researches (grant no: 2007/4) which was received by Baccioglu Kavut, and Kalpaklioglu.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.aller.2012.05.006
dc.identifier.endpage380en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue6en_US
dc.identifier.pmid23031657
dc.identifier.scopus2-s2.0-84888844552
dc.identifier.scopusqualityQ3
dc.identifier.startpage374en_US
dc.identifier.urihttps://doi.org/10.1016/j.aller.2012.05.006
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5426
dc.identifier.volume41en_US
dc.identifier.wosWOS:000328809500005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Doyma Slen_US
dc.relation.ispartofAllergologia Et Immunopathologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergic rhinitisen_US
dc.subjectCorticosteroiden_US
dc.subjectIgEen_US
dc.subjectNeurogenicen_US
dc.subjectNon-allergic rhinitisen_US
dc.subjectTreatmenten_US
dc.subjectTriamcinoloneen_US
dc.titleEfficacy and safety of once daily triamcinolone acetonide aqueous nasal spray in adults with non-allergic and allergic rhinitisen_US
dc.typeArticle

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