Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis

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dc.authoridAldhahi, Monira/0000-0002-5255-4860
dc.authoridYAGIN, Fatma Hilal/0000-0002-9848-7958
dc.authoridEken, Ozgur/0000-0002-5488-3158
dc.contributor.authorAl-Mhanna, Sameer Badri
dc.contributor.authorRocha-Rodriguesc, Silvia
dc.contributor.authorMohamed, Mahaneem
dc.contributor.authorBatrakoulis, Alexios
dc.contributor.authorAldhahi, Monira I.
dc.contributor.authorAfolabi, Hafeez Abiola
dc.contributor.authorYagin, Fatma Hilal
dc.date.accessioned2025-01-21T16:38:15Z
dc.date.available2025-01-21T16:38:15Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground Lifestyle modifications involving diet and exercise are recommended for patients diagnosed with obesity and type 2 diabetes mellitus (T2DM). The purpose of this review was to systematically evaluate the effects of combined aerobic exercise and diet (AEDT) on various cardiometabolic health-related indicators among individuals with obesity and T2DM.Methodology A comprehensive search of the PubMed/Medline, Web of Science, Scopus, Science Direct, Cochrane, and Google Scholar databases was conducted for this meta-analysis. The Cochrane risk of bias tool was used to evaluate eligible studies, and the GRADE tool was used to rate the certainty of evidence. A random-effects model for continuous variables was used, and the results were presented as mean differences or standardised mean differences with 95% confidence intervals.Results A total of 16,129 studies were retrieved; 20 studies were included, and data were extracted from 1,192 participants. The findings revealed significant improvements in body mass index, body weight, waist circumference, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, fasting blood glucose, fasting plasma insulin, glycated hemoglobin, leptin, interleukin-6, C-reactive protein, and adiponectin (p < 0.05) compared to the standard treatment (ST) group. No significant differences were observed between the AEDT and ST groups in fat mass, hip circumference, waist-to-hip ratio, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and tumor necrosis factor-alpha. The present findings are based on low- to moderate-quality evidence.Conclusions AEDT may be a critical behavior for holistic cardiometabolic health-related benefits as a contemporary anti-obesity medication due to its significant positive impact on patients with obesity and T2DM. Nevertheless, further robust evidence is necessary to determine whether AEDT is an effective intervention for lowering cardiovascular and metabolic risk factors among individuals with obesity and T2DM.
dc.description.sponsorshipPrincess Nourah Bint Abdulrahman University [304]; School of Medical Sciences at the Universiti Sains Malaysia
dc.description.sponsorshipThe authors acknowledge the School of Medical Sciences at the Universiti Sains Malaysia for the support in this project (No.: 304.PPSP.6315639).
dc.identifier.doi10.1186/s13102-023-00766-5
dc.identifier.issn2052-1847
dc.identifier.issue1
dc.identifier.pmid38049873
dc.identifier.scopus2-s2.0-85178429850
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s13102-023-00766-5
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24613
dc.identifier.volume15
dc.identifier.wosWOS:001113726400002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofBmc Sports Science Medicine and Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectPhysical activity; Exercise; Overweight; Metabolic syndrome; Lifestyle intervention
dc.titleEffects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis
dc.typeReview Article

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