Apparent diffusion coefficient variabilities of the optic nerve in multiple sclerosis: Optic nerve head and intraorbital segment

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dc.contributor.authorŞahan M.H.
dc.contributor.authorİnal M.
dc.contributor.authorAsal N.
dc.contributor.authorGökçınar N.B.
dc.date.accessioned2020-06-25T15:18:11Z
dc.date.available2020-06-25T15:18:11Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractTo investigate the diffusion alterations in the optic nerve head/intraorbital segment in Multiple sclerosis (MS) patients (with or without a history of optic neuritis) in comparison with healthy controls. MS group consisted of 57 patients who had previously been diagnosed with MS. A total of 234 eyes which consisted of 114 eyes of the MS patients and 120 eyes of the healthy controls, were investigated. In 16 of the MS patients had the history of optic neuritis in one eye. The control group was selected from healthy subjects who were matched with MS patients group in terms of gender and age. Echo planar imaging (EPI) sequence was benefitted to attain diffusion-weighted images (DWI). The optic nerve head/intraorbital segment apparent diffusion-coefficient (ADC) values of two groups were compared. The difference between the optic nerve head/intra-orbital segment ADC values of control group and MS patients was found statistically considerable (P=0.009, P=0.006, respectively). The difference between the optic nerve head/intra-orbital segment ADC values of MS patients without optic neuritis and control group was also found statistically considerable (P= 0.016, P= 0.026, respectively). It was found that there is a positive correlation between the ADC values and duration of the disease in MS patients (R=0.485/0.428, P<0.01). The ADC values of the optic nerve head/intraorbital segment measured by ocular DWI may have potential for MS patients in the future and this method deserves additional validation in the disease staging and more work to pred ict patients at risk of optic neuritis. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.en_US
dc.identifier.citationŞahan, M. H., İnal, M., Asal, N., Gökçınar, N. B. (2019). Apparent Diffusion Coefficient Variabilities of the Optic Nerve in Multiple Sclerosis: Optic Nerve Head and Intraorbital Segment. Eastern Journal of Medicine, 24(2), 242 - 248.en_US
dc.identifier.doi10.5505/ejm.2019.04934
dc.identifier.endpage248en_US
dc.identifier.issn13010883
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85065848744
dc.identifier.scopusqualityQ4
dc.identifier.startpage242en_US
dc.identifier.trdizinid326571
dc.identifier.urihttps://doi.org/10.5505/ejm.2019.04934
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2652
dc.identifier.volume24en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherYuzuncu Yil Universitesi Tip Fakultesien_US
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiffusion-weighted imagingen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectMultiple sclerosisen_US
dc.subjectOptic nerveen_US
dc.titleApparent diffusion coefficient variabilities of the optic nerve in multiple sclerosis: Optic nerve head and intraorbital segmenten_US
dc.typeArticle

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