Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients

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dc.contributor.authorKorucu, Berfu
dc.contributor.authorDerici, Mehmet Kursat
dc.contributor.authorDeger, Serpil Muge
dc.contributor.authorCokay, Abdurrahman
dc.contributor.authorHelvaci, Ozant
dc.contributor.authorElbeg, Sehri
dc.contributor.authorDerici, Ulver
dc.date.accessioned2021-01-14T18:10:44Z
dc.date.available2021-01-14T18:10:44Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractObjective: Adipocyte fatty acid-binding protein (A-FABP) is expressed in adipose tissue and macrophages. It regulates cholesterol trafficking and is involved in atherosclerosis formation. A-FABP levels are associated with cardiovascular diseases (CVDs) in patients with or without chronic kidney disease. In this study, we evaluated A-FABP levels in healthy controls and hemodialysis (HD) patients and compared the results with C-reactive protein (CRP) and interleukin-6 (IL-6) levels to determine their relationship with systemic inflammation. Materials and Methods: The study comprised 23 healthy controls and 70 HD patients, excluding individuals with an active infection, malignancy, anorexia, obesity, and hypo- or hyperthyroidism. Demographic features, laboratory findings, A-FABP levels, and levels of inflammatory markers were evaluated between and within the groups. Results: Levels of A-FABP and inflammatory markers were significantly higher in HD patients. In the HD group, 20% of the patients had documented CVD. Levels of A-FABP and inflammatory markers were similar in nondiabetic and diabetic HD patients. Age was negatively correlated with A-FABP levels. Presence of diabetes was not correlated with A-FABP. Serum CRP and IL-6 levels were significantly correlated with A-FABP levels (r=0.354, p=0.003 and r=0.393, p=0.001, respectively). Conclusion: A-FABP levels are elevated in HD patients. Systemic inflammation is significantly related to A-FABP levels in both nondiabetic and diabetic HD patients and decreases with age. Findings of this study support the adverse cardiovascular effects of systemic inflammation in HD patients.en_US
dc.description.sponsorshipGazi University School of MedicineGazi Universityen_US
dc.description.sponsorshipThe authors declared that this study has received financial support from the Gazi University School of Medicine Scientific Research and Project Unit.en_US
dc.identifier.citationKorucu B, Derici MK, Değer SM, Çokay A, Helvacı Ö, Elbeg Ş, et al. Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. Turk J Nephrol 2020; 29(2): 115-21.en_US
dc.identifier.doi10.5152/turkjnephrol.2020.3686
dc.identifier.endpage121en_US
dc.identifier.issn2667-4440
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85087965601
dc.identifier.scopusqualityQ4
dc.identifier.startpage115en_US
dc.identifier.trdizinid423207
dc.identifier.urihttps://doi.org/10.5152/turkjnephrol.2020.3686
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12749
dc.identifier.volume29en_US
dc.identifier.wosWOS:000533604700003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAVESen_US
dc.relation.ispartofTURKISH JOURNAL OF NEPHROLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdipocyte fatty acid-binding proteinen_US
dc.subjectcardiovascular diseasesen_US
dc.subjecthemodialysisen_US
dc.subjectsystemic inflammationen_US
dc.titleRelationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patientsen_US
dc.typeArticle

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