Frequency and status of depression and anxiety in mothers of children with inborn errors of metabolism with restricted diet, with and without risk of metabolic crises

Basit Öğe Kaydı
dc.contributor.authorKisa, Pelin Teke
dc.contributor.authorUzun, Ozlem Unal
dc.contributor.authorGunduz, Mehmet
dc.contributor.authorBulbul, Fatma Selda
dc.contributor.authorKose, Engin
dc.contributor.authorArslan, Nur
dc.date.accessioned2025-01-21T16:41:14Z
dc.date.available2025-01-21T16:41:14Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: This study aimed to investigate the frequency and status of depression and anxiety among mothers of children with inborn errors of metabolism (IEM) who were on a restricted diet and previously experienced metabolic crises. Methods: This cross-sectional multicenter descriptive study included 93 children with IEM who were on restricted diet. The patients were divided into two groups: those who had experienced metabolic crises (n=44, urea cycle defect, organic acidemia, maple syrup urine disease, hereditary fructose intolerance) and those who had not experienced previous metabolic crises (n=49; phenylketonuria, galactosemia, and nonketotic hyperglycinemia). The control group comprised 37 healthy children. The mothers of the patients and control participants answered a questionnaire about their and their children's demographic and clinical characteristics and completed the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI-S and STAI-T). Results: The maternal BDI, STAI-S, and STAI-T scores were 6.3 +/- 5.2, 36.1 +/- 11.2, and 39.9 +/- 8.8, respectively, in the control group. The maternal BDI, STAI-S, and STAI-T scores of the children who had experienced (19.2 +/- 9.7; 44.0 +/- 12.4; 47.9 +/- 10.6) and those who had not experienced (13.9 +/- 9.1; 40.7 +/- 8.6; 45.3 +/- 8.3) a crisis were significantly higher than for the controls. The BDI score was significantly higher for the mothers of children who had experienced a crisis (p=0.011), whereas no significant difference was determined between the two patient groups regarding STAI-S and STAI-T scores. The mothers of four children who had experienced metabolic crises were on antidepressant therapy. Conclusion: Although their children were on a similar restricted diet, the mothers of children who previously experienced or who had the risk of experiencing metabolic crises had higher depression scores as compared with the mothers of children who did not experience a previous crisis. Early supportive therapy may be required for the families of these patients to lower the burden of stress. (C) 2021 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.
dc.identifier.doi10.1016/j.arcped.2021.09.008
dc.identifier.endpage706
dc.identifier.issn0929-693X
dc.identifier.issn1769-664X
dc.identifier.issue8
dc.identifier.pmid34620546
dc.identifier.scopus2-s2.0-85116484664
dc.identifier.scopusqualityQ2
dc.identifier.startpage702
dc.identifier.urihttps://doi.org/10.1016/j.arcped.2021.09.008
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24846
dc.identifier.volume28
dc.identifier.wosWOS:000722082100015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofArchives De Pediatrie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectMetabolic crises; Inborn errors of metabolism; Anxiety; Depression; Mother
dc.titleFrequency and status of depression and anxiety in mothers of children with inborn errors of metabolism with restricted diet, with and without risk of metabolic crises
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu