Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries-The @IT.2020 multicenter study

Basit Öğe Kaydı
dc.authoridCaeiro, Elsa/0000-0001-8717-4596
dc.authoridPereira, Ana Margarida/0000-0002-5468-0932
dc.authoridGrittner, Ulrike/0000-0003-2595-0224
dc.authoridDelgado, Luis/0000-0003-2375-9071
dc.authoridPotapova, Ekaterina/0000-0003-4427-6335
dc.authoridDramburg, Stephanie/0000-0002-9303-3260
dc.authoridHernandez-Toro, Camilo/0000-0003-1242-9018
dc.contributor.authorDramburg, S.
dc.contributor.authorGrittner, U.
dc.contributor.authorPotapova, E.
dc.contributor.authorTravaglini, A.
dc.contributor.authorTripodi, S.
dc.contributor.authorArasi, S.
dc.contributor.authorPelosi, S.
dc.date.accessioned2025-01-21T16:41:26Z
dc.date.available2025-01-21T16:41:26Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Pollen allergy poses a significant health and economic burden in Europe. Disease patterns are relatively homogeneous within Central and Northern European countries. However, no study broadly assessed the features of seasonal allergic rhinitis (SAR) across different Southern European countries with a standardized approach. Objective: To describe sensitization profiles and clinical phenotypes of pollen allergic patients in nine Southern European cities with a uniform methodological approach. Methods: Within the @IT.2020 multicenter observational study, pediatric and adult patients suffering from SAR were recruited in nine urban study centers located in seven countries. Clinical questionnaires, skin prick tests (SPT) and specific IgE (sIgE) tests with a customized multiplex assay (Euroimmun Labordiagnostika, Lubeck, Germany) were performed. Results: Three hundred forty-eight children (mean age 13.1 years, SD: 2.4 years) and 467 adults (mean age 35.7 years SD: 10.0 years) with a predominantly moderate to severe, persistent phenotype of SAR were recruited. Grass pollen major allergenic molecules (Phl p 1 and/or Phl p 5) ranged among the top three sensitizers in all study centers. Sensitization profiles were very heterogeneous, considering that patients in Rome were highly poly-sensitized (sIgE to 3.8 major allergenic molecules per patient), while mono-sensitization was prominent and heterogeneous in other cities, such as Marseille (sIgE to Cup a 1: n = 55/80, 68.8%) and Messina (sIgE to Par j 2: n = 47/82, 57.3%). Co-sensitization to perennial allergens, as well as allergic comorbidities also broadly varied between study centers. Conclusions: In Southern European countries, pollen allergy is heterogeneous in terms of sensitization profiles and clinical manifestations. Despite the complexity, a unique molecular, multiplex, and customized in-vitro IgE test detected relevant sensitization in all study centers. Nevertheless, this geographical diversity in pollen allergic patients imposes localized clinical guidelines and study protocols for clinical trials of SAR in this climatically complex region.
dc.description.sponsorshipEuroimmun; [118583]
dc.description.sponsorshipThis study was supported by an unrestricted educational grant from Euroimmun (code 118583). We thank all participants and the entire study team. We remember our esteemed colleague Giovanni Battista Pajno who passed away on April 11, 2022 and whose remarkable work has contributed significantly to this project, but also to research in allergology and Immunology in general. Open Access funding enabled and organized by Projekt DEAL.
dc.identifier.doi10.1111/all.16029
dc.identifier.endpage923
dc.identifier.issn0105-4538
dc.identifier.issn1398-9995
dc.identifier.issue4
dc.identifier.pmid38311961
dc.identifier.scopus2-s2.0-85184226901
dc.identifier.scopusqualityQ1
dc.identifier.startpage908
dc.identifier.urihttps://doi.org/10.1111/all.16029
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24888
dc.identifier.volume79
dc.identifier.wosWOS:001157671700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAllergy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectallergic rhinitis; component-resolved diagnostics; IgE; phenotypes; pollen allergy; sensitization
dc.titleHeterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries-The @IT.2020 multicenter study
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu