Investigation of choroidal structure changes after intravitreal anti-VEGF therapy for retinal vein occlusion

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dc.authoridDursun, Erdem/0000-0002-4320-9336
dc.authoridDerhem, Baki/0000-0002-6989-9873
dc.authoridOgurel, Tevfik/0000-0003-0658-2286
dc.contributor.authorDursun, Erdem
dc.contributor.authorDerhem, Baki
dc.contributor.authorCobanoglu, Seval
dc.contributor.authorOgurel, Tevfik
dc.date.accessioned2025-01-21T16:41:55Z
dc.date.available2025-01-21T16:41:55Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground We aimed to investigate the effect of retinal vein occlusion (RVO) on the posterior segment structures of the eye and its changes with intravitreal anti-Vascular Endothelial Growth Factor (VEGF) treatment. Methods This prospective longitudinal study included 29 eyes of 29 patients with RVO (17 males and 12 females) followed for 6 months. The best corrected visual acuity (BCVA), macula, choroid ticknesses and choroidal vascularity index (CVI) obtained by spectral-domain optical coherence tomography were recorded at baseline and the first, third, and sixth months after the first injection. Results were compared with fellow eyes (non-affected eyes) and age- and sex-matched controls. Results BCVA increased significantly in the 6th month, more in the first month of injection (p < 0.05 for each). Central macular tickness, subfoveal choroid tickness, stromal and total area of choroid decreased significantly after injection (p < 0.05 for each). CVI values increased significantly, especially in the 1st month after injection (p < 0.05 for each). In eyes with Branch RVO, there was a significant decrease in the macular thickness of the occlusive areas with treatment, while there was no statistically significant change in the non-occlusive macular thickness. Conclusion Observation of changes in choroidal structure may be useful to assess the activity of RVO and predict the efficacy of anti-VEGF therapy.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK)
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUBITAK).
dc.identifier.doi10.1007/s00417-024-06562-2
dc.identifier.endpage3845
dc.identifier.issn0721-832X
dc.identifier.issn1435-702X
dc.identifier.issue12
dc.identifier.pmid39037469
dc.identifier.scopus2-s2.0-85199286255
dc.identifier.scopusqualityQ1
dc.identifier.startpage3837
dc.identifier.urihttps://doi.org/10.1007/s00417-024-06562-2
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24980
dc.identifier.volume262
dc.identifier.wosWOS:001274317000002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofGraefes Archive For Clinical and Experimental Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectRetinal vein occlusion; Choroid thickness; Central macular thickness; Vascular endothelial growth factor; Choroid vascularity index
dc.titleInvestigation of choroidal structure changes after intravitreal anti-VEGF therapy for retinal vein occlusion
dc.typeArticle

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