Inconsistencies of the Disease Activity Assessment Tools for Psoriatic Arthritis: Challenges to Rheumatologists

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dc.authoridmulkoglu, cevriye/0000-0001-9113-3885
dc.authoridSen, Nesrin/0000-0003-0966-0075
dc.authoridAcer Kasman, Sevtap/0000-0002-4805-0555
dc.authoridDuruoz, Mehmet Tuncay/0000-0003-3584-2788
dc.authoridTEKEOGLU, IBRAHIM/0000-0003-3395-7178
dc.authoridNAS, Kemal/0000-0002-5845-0851
dc.authoridYurdakul, Ozan Volkan/0000-0003-4567-8133
dc.contributor.authorGezer, Halise Hande
dc.contributor.authorDuruoz, Mehmet Tuncay
dc.contributor.authorNas, Kemal
dc.contributor.authorKilic, Erkan
dc.contributor.authorSargin, Betul
dc.contributor.authorKasman, Sevtap Acer
dc.contributor.authorAlkan, Hakan
dc.date.accessioned2025-01-21T16:41:44Z
dc.date.available2025-01-21T16:41:44Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Currently, concerning the evaluation of psoriatic arthritis (PsA), there is no agreement on a standardized composite index for disease activity that includes all relevant domains. The present study sought to assess the rates of remission (REM)/low disease activity (LDA) and disease states [minimal disease activity (MDA), very low disease activity (VLDA)] as defined by diverse activity scales (DAPSA, DAS28-ESR) in an attempt to display discrepancies across these assessment tools for peripheral PsA. Methods: The study involved 758 patients (496 females, 262 males; mean age 47,1 years) with peripheral PsA who were registered to the Turkish League Against Rheumatism (TLAR) Network. The patients were assessed using the DAS28-ESR, DAPSA, MDA, and VLDA. The overall yield of each scale was assessed in identifying REM and LDA. The presence or absence of swollen joints was separately analysed. Results: The median disease duration was 4 years (range 0-44 years). According to DAPSA and DAS28-ESR, REM was achieved in 6.9% and 19.5% of the patients, respectively. The rates of MDA and VLDA were 16% and 2.9%, respectively. Despite the absence of swollen joints, a significant portion of patients were not considered to be in REM (296 (39.1%) patients with DAS28-ESR, 364 (48%) with DAPSA, and 394 (52%) with VLDA). Conclusion: Patients with peripheral PsA may be assigned to diverse disease activity levels when assessed with the DAS28-ESR, DAPSA, MDA and VLDA, which would inevitably have clinical implications. In patients with PsA a holistic approach seems to be necessary which includes other domains apart from joint involvement, such as skin involvement, enthesitis, spinal involvement, and patient-reported outcomes. (C) 2021 Societe franc , aise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
dc.description.sponsorshipTurkish League Against Rheumatism (TLAR)
dc.description.sponsorshipThis work was supported by the Turkish League Against Rheumatism (TLAR) .
dc.identifier.doi10.1016/j.jbspin.2021.105296
dc.identifier.issn1297-319X
dc.identifier.issn1778-7254
dc.identifier.issue3
dc.identifier.pmid34656752
dc.identifier.scopus2-s2.0-85118218068
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jbspin.2021.105296
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24938
dc.identifier.volume89
dc.identifier.wosWOS:000718034300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofJoint Bone Spine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectRemission; Disease activity; Psoriatic arthritis; Composite index
dc.titleInconsistencies of the Disease Activity Assessment Tools for Psoriatic Arthritis: Challenges to Rheumatologists
dc.typeArticle

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