A 6-month in vivo study of polymer/mesenchymal stem cell constructs for cranial defects

Basit Öğe Kaydı
dc.contributor.authorAydın, Halil Murat
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorVargel, İbrahim
dc.contributor.authorKılıç, Emine
dc.contributor.authorGüzel, Elif
dc.contributor.authorÇavuşoğlu, Tarık
dc.contributor.authorPişkin, Erhan
dc.date.accessioned2020-06-25T17:51:59Z
dc.date.available2020-06-25T17:51:59Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.descriptionMeydanli, E. Elif Guzel/0000-0001-9072-3322; KILIC, Emine/0000-0003-2984-7638; KORKUSUZ, PETEK/0000-0002-7553-3915
dc.description.abstractTwo biodegradable polymers, poly(L-lactide) and poly(epsilon-caprolactone) were blended (50/50) and used to produce polymeric scaffolds by the dual porogen approach using a salt leaching technique to create pores within the matrix, while supercritical-CO2 treatment was used to enhance the interconnectivity and to remove impurities from synthesis steps. The scaffolds were highly porous (porosity >90%) with interconnected pore morphologies. These biodegradable scaffolds were evaluated in Sprague Dawley rats for osteoconductive properties over a 6-month period. Bone specimens were analyzed after 1, 3, and 6 months, for bone healing and tissue response. The cortical bone remodeling by controlled osteoblastic and osteoclastic activities as well as the bone marrow elements recovery were semi-quantitatively examined for each group. Excellent integration and biocompatibility behavior was observed in all groups. No adverse tissue responses were observed.en_US
dc.description.sponsorshipEXPERTISSUES Network of Excellence (NoE) [NMP3-CT-2004-500283]; Turkish Ministry of Industry and TradeMinistry of Science, Industry & Technology - Turkey [00020.STV.2006-1]; Turkish Scientific and Technological Research CouncilTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [105T509]; Turkish Academy of SciencesTurkish Academy of Sciencesen_US
dc.description.sponsorshipThis project was partly supported by EXPERTISSUES Network of Excellence (NoE)-NMP3-CT-2004-500283, Turkish Ministry of Industry and Trade (San-Tez Project No: 00020.STV.2006-1), and Genkord A. S,. in combination with the Turkish Scientific and Technological Research Council TissueBiomed, project no: 105T509. Erhan Piskin was supported by Turkish Academy of Sciences as a full member. The authors acknowledge Dr Thomas Kohler and Prof Ralph Muller for micro-CT analysis.en_US
dc.identifier.citationAydin HM, Korkusuz P, Vargel İ, et al. A 6-month in vivo study of polymer/mesenchymal stem cell constructs for cranial defects. Journal of Bioactive and Compatible Polymers. 2011;26(2):207-221.en_US
dc.identifier.doi10.1177/0883911511399411
dc.identifier.endpage221en_US
dc.identifier.issn0883-9115
dc.identifier.issn1530-8030
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-79956092612
dc.identifier.scopusqualityQ3
dc.identifier.startpage207en_US
dc.identifier.urihttps://doi.org/10.1177/0883911511399411
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5047
dc.identifier.volume26en_US
dc.identifier.wosWOS:000288783600008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of Bioactive And Compatible Polymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbiodegradable scaffoldsen_US
dc.subjectbone marrowen_US
dc.subjectbone tissue engineeringen_US
dc.subjectin vivo studyen_US
dc.subjectosteoclastic activityen_US
dc.subjectpolymeric blendsen_US
dc.subjectsalt leachingen_US
dc.subjectsupercritical CO2en_US
dc.titleA 6-month in vivo study of polymer/mesenchymal stem cell constructs for cranial defectsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
A 6-month in vivo study of polymer mesenchymal stem cell constructs for cranial defects.pdf
Boyut:
834.73 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu