GSTP1 Levels in Cisplatin-induced Rat Cochlea after Alpha Lipoic Acid and Oxytocin Treatment

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dc.contributor.authorAydin, Sedat
dc.contributor.authorDemir, Mehmet Gokhan
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorAltintoprak, Niyazi
dc.contributor.authorBilmez, Eda Bekmez
dc.contributor.authorGul, Aylin Ege
dc.contributor.authorKocdogan, Arzu Kaya
dc.date.accessioned2020-06-25T18:22:39Z
dc.date.available2020-06-25T18:22:39Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptiondemir, mehmet/0000-0002-0609-6782; aydin, sedat/0000-0003-4939-5026
dc.description.abstractIntroduction: Cisplatin is a well-known chemotherapeutic agent used in many cancer treatments. Several antioxidant agents are used for diminishing the toxic side effects of the cisplatin therapy. Alpha-lipoic acid (alpha-LA) and oxytocin (OT) are antioxidant agents that can be used in toxicity. Our aim is to investigate the effect of these antioxidants in cisplatin-induced ototoxicity in tissue level. Materials and Methods: Forty Wistar albino rats divided into five groups as control, cisplatin, cisplatin + intraperitoneal (IP) OT, cisplatin + intratympanic (IT) OT, and cisplatin + IT alpha-LA. The drug administration is applied for 4 days, and at the end of the procedure, the cochleas are harvested. After tissue preparation, GSTP1 levels are investigated and the intensity of the reaction is scored as negative (-), weak (1+), moderate (2+), or strong (3+). Results: Group 4 has a moderate staining which can be interpreted as high immunoreaction. When we compare with Group 1, this staining difference is statistically significant (P < 0.02). When we observe the Group 3, we cannot detect any difference with Group 1 in immunoreactivity. Conclusion: alpha-LA and OT are antioxidants effective against cisplatin ototoxicity. The expression of GSTP1 isozyme is increased in antioxidant-treated groups. Increased levels of these isozymes proved the increased healing response in tissue levels. Antioxidant agents can be used for adverse effects during cisplatin treatment. IT route is effective as IP systemic route.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.4103/indianjotol.INDIANJOTOL_137_16
dc.identifier.endpage240en_US
dc.identifier.issn0971-7749
dc.identifier.issn2249-9520
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85046704006
dc.identifier.scopusqualityQ4
dc.identifier.startpage237en_US
dc.identifier.urihttps://doi.org/10.4103/indianjotol.INDIANJOTOL_137_16
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6850
dc.identifier.volume23en_US
dc.identifier.wosWOS:000431853300006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofIndian Journal Of Otology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-lipoic aciden_US
dc.subjectcisplatinen_US
dc.subjectGSTP1en_US
dc.subjectototoxicityen_US
dc.subjectoxytocinen_US
dc.titleGSTP1 Levels in Cisplatin-induced Rat Cochlea after Alpha Lipoic Acid and Oxytocin Treatmenten_US
dc.typeArticle

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