Influence of circadian blood pressure alterations on serum SCUBE-1 and soluble CD40 ligand levels in patients with essential hypertension

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dc.contributor.authorGuzel, Murat
dc.contributor.authorDogru, Mehmet Tolga
dc.contributor.authorSimsek, Vedat
dc.contributor.authorDemir, Vahit
dc.contributor.authorAlp, Caglar
dc.contributor.authorKandemir, Huseyin
dc.contributor.authorKisa, Ucler
dc.date.accessioned2020-06-25T18:34:28Z
dc.date.available2020-06-25T18:34:28Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractBackground: Dipper and non-dipper hypertension are different clinical forms of essential hypertension. In this study, the effect of circadian blood pressure changes on serum SCUBE-1 and soluble CD40 ligand (sCD40L) levels was investigated in patients with hypertension. Methods: A total of 100 participants aged 23-89 years were included in the study. Patients with essential hypertension were followed up by ambulatory blood pressure measurement. Results: Serum SCUBE1 levels were significantly higher in the non-dipper group than in the normal group (P < 0.001). Dipper and non-dipper patients had significantly higher serum sCD40L levels when compared to the normal group (P = 0.048 and P = 0.035, respectively). We also found a positive correlation between SCUBE1, sCD40L levels and 24-hour mean systolic blood pressure levels (r: 0.232, p: 0.034 and r: 0.241, p: 0.027, respectively). Conclusion: Serum SCUBE1 and sCD40L levels were higher in hypertensive patients than normal participants. Serum SCUBE1 levels were higher in patients with non-dipper compared to other participants.en_US
dc.identifier.citationGuzel M, Dogru MT, Simsek V, Demir V, Alp C, Kandemir H, Yildirim N, Kisa U. Influence of circadian blood pressure alterations on serum SCUBE-1 and soluble CD40 ligand levels in patients with essential hypertension. Am J Cardiovasc Dis. 2019 Aug 15;9(4):42-48.en_US
dc.identifier.endpage48en_US
dc.identifier.issn2160-200X
dc.identifier.issue4en_US
dc.identifier.pmid31516762
dc.identifier.startpage42en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7924
dc.identifier.volume9en_US
dc.identifier.wosWOS:000485155700003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofAmerican Journal Of Cardiovascular Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSCUBE1 protein humanen_US
dc.subjectsCD40L proteinen_US
dc.subjecthypertensionen_US
dc.subjectblood pressure monitoringen_US
dc.titleInfluence of circadian blood pressure alterations on serum SCUBE-1 and soluble CD40 ligand levels in patients with essential hypertensionen_US
dc.typeArticle

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