Describing the Expression Profiles of Glutathione S-Transferase Mu and Tumor Protein 53 in Brain Tumor Tissue

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dc.authoridDirican, Onur/0000-0003-0511-6611
dc.contributor.authorDirican, Onur
dc.contributor.authorKaygın, Pınar
dc.contributor.authorSarıaltın, Sezen Yılmaz
dc.contributor.authorYılmaz, Can
dc.contributor.authorŞimşek, Gülçin
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorÇoban, Tülay
dc.date.accessioned2025-01-21T16:34:13Z
dc.date.available2025-01-21T16:34:13Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: This study aims to explore the expression profiles of the glutathione S-transferaseMu (GST-M) isozyme and tumor protein 53 (p53) in both healthy and tumorous brain tissues. The findings are compared with clinical features and lifestyle factors to identify potential associations or correlations. Materials and Methods: We retrospectively analyzed the medical records of 149 patients diagnosed with primary or metastatic intracranial tumors. The expression levels of GST-M and p53 proteins were assessed in healthy and tumorous brain tissues using immunohistochemical staining. We also evaluated the associated clinical features and lifestyle factors. Results: There was a significant difference in the expression levels of GST-M between tumorous and healthy brain tissues, with tumor tissues showing higher expression (p<0.0001). Conversely, robust p53 expression was absent in both normal (97.3%) and tumor (78.5%) tissues. Nevertheless, a significantly higher prevalence of samples with p53 expression was found in the tumor group (p<0.0001). No associations were found between expression levels and clinical features or lifestyle risk factors. Furthermore, GST-M and p53 expression did not impact postoperative survival rates. Conclusion: The findings indicate an elevated expression of GST-M in brain tumor tissues, suggesting a potential role for GST-M in brain tumorigenesis.
dc.identifier.doi10.14744/cpr.2024.77834
dc.identifier.endpage223
dc.identifier.issn2980-2156
dc.identifier.issue3
dc.identifier.startpage214
dc.identifier.trdizinid1281279
dc.identifier.urihttps://doi.org/10.14744/cpr.2024.77834
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1281279
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23912
dc.identifier.volume46
dc.identifier.wosWOS:001244721800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherErciyes Univ Sch Medicine
dc.relation.ispartofJournal of Clinical Practice and Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBrain cancer; immunohistochemistry; glutathione S-transferase; tumor protein 53; lifestyle
dc.titleDescribing the Expression Profiles of Glutathione S-Transferase Mu and Tumor Protein 53 in Brain Tumor Tissue
dc.typeArticle

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