The Role of AMACR, CD10, TMPRSS2-ERG, and p27 Protein Expression Among Different Gleason Grades of Prostatic Adenocarcinoma on Needle Biopsy

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dc.contributor.authorGulhan, Ozdemir
dc.contributor.authorMahi, Balci
dc.date.accessioned2021-01-14T18:10:28Z
dc.date.available2021-01-14T18:10:28Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractObjective: We examined the immunohistochemical expression of alpha-methyl acyl coenzyme A racemase (AMACR), CD10, TMPRSS2-ERG, and p27 in prostate adenocarcinoma tumors with different Gleason growth patterns and nonneoplastic prostate tissues to elucidate their roles in prostate carcinogenesis and histological aggressiveness. Material and Methods: In total, 80 archival core biopsy tissues diagnosed as prostate carcinoma, benign prostate hyperplasia, and atrophy cases were included. Immunoreactivity was evaluated by calculating the percentage of positively stained cells and the staining intensity. The mean values and test of significance were obtained using the Kruskal-Wallis test. Results: We obtained mostly intense immunoreactivity for AMACR, CD10, and ERG in adenocarcinomas. Although no significant differences were noted regarding AMACR and ERG expression, samples with Gleason growth patterns 3 and 5 tended to be strongly positive for ERG. Pattern 3 tumors exhibited the weakest positivity for CD10. The p27 expression was strong and diffuse in nonneoplastic prostate tissues. The loss of p27 expression was more frequent for pattern 5 tumors. Conclusion: ERG and AMACR were powerful markers to detect cancer. Especially, ERG is evident in early tumors may reflect its interaction with functional androgen receptors in cancer initiation. Pattern 5 tumors associated with stroma may have been exposed to more stromal substrates and upregulate their CD10 content as a protein degrader. We suggest that CD10 expression is associated with an increasing tumor grade. Decreased concentrations of p27 protein might be implicated in prostate carcinogenesis and may be a useful immunohistochemical adjunct in predicting histological aggressiveness.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects UnitKirikkale University [2018/073]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Kirikkale University Scientific Research Projects Unit with project code number 2018/073.en_US
dc.identifier.citationGülhan Ö, Mahi B. The Role of AMACR, CD10, TMPRSS2-ERG, and p27 Protein Expression Among Different Gleason Grades of Prostatic Adenocarcinoma on Needle Biopsy. Clinical Medicine Insights: Oncology. 2020;14.en_US
dc.identifier.doi10.1177/1179554920947322
dc.identifier.issn1179-5549
dc.identifier.pmid35185351
dc.identifier.scopus2-s2.0-85089175468
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1177/1179554920947322
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12618
dc.identifier.volume14en_US
dc.identifier.wosWOS:000559744500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofCLINICAL MEDICINE INSIGHTS-ONCOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProstate adenocarcinomaen_US
dc.subjectGleason scoreen_US
dc.subjectAMACRen_US
dc.subjectCD10en_US
dc.subjectTMPRSS2-ERGen_US
dc.subjectp27en_US
dc.titleThe Role of AMACR, CD10, TMPRSS2-ERG, and p27 Protein Expression Among Different Gleason Grades of Prostatic Adenocarcinoma on Needle Biopsyen_US
dc.typeArticle

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