Molecular genetic analysis of two large kindreds with intracranial aneurysms demonstrates linkage to 11q24-25 and 14q23-31

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dc.contributor.authorÖztürk, Ali K.
dc.contributor.authorNahed, BV
dc.contributor.authorBydon, M
dc.contributor.authorBilguvar, Kaya
dc.contributor.authorGöksu, Ethem
dc.contributor.authorBademci, Gülşah
dc.contributor.authorGünel, Murat
dc.date.accessioned2020-06-25T17:41:00Z
dc.date.available2020-06-25T17:41:00Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.descriptionNahed, Brian/0000-0001-8537-106X
dc.description.abstractBackground and Purpose - Both environmental and genetic factors contribute to the formation, growth, and rupture of intracranial aneurysms (IAs). To search for IA susceptibility genes, we took an outlier approach, using parametric genome-wide linkage analysis in extended IA kindreds in which IA is inherited as a simple Mendelian trait. We hereby present the molecular genetic analysis of 2 such families. Methods - For genome-wide linkage analysis, we used a 2-stage approach. First, using gene chips in affected-only analysis, we identified genomic regions that provide maximum theoretical logarithm of odds (lod) scores. Next, to confirm or exclude these candidate loci, we genotyped all available family members, both affected and unaffected, using polymorphic microsatellite markers located within these regions. Results - We obtained significant lod scores of 4.3 and 3.00 for linkage to chromosomes 11q24-25 and 14q23-31, respectively. Conclusions - Molecular genetic analysis of 2 large IA kindreds confirms linkage to chromosome 11q and 14q, which were suggested to contain IA susceptibility genes in a previous study of Japanese sib pairs. Independent identification of these 2 loci strongly suggests that IA susceptibility genes lie within these regions. While demonstrating the genetic heterogeneity of IA, these results are also an important step toward cloning IA genes and ultimately understanding its pathophysiology.en_US
dc.identifier.citationOzturk, A. K., Nahed, B. V., Bydon, M., Bilguvar, K., Goksu, E., Bademci, G., Guclu, B., Johnson, M. H., Amar, A., Lifton, R. P., & Gunel, M. (2006). Molecular genetic analysis of two large kindreds with intracranial aneurysms demonstrates linkage to 11q24-25 and 14q23-31. Stroke, 37(4), 1021–1027. https://doi.org/10.1161/01.STR.0000206153.92675.b9en_US
dc.identifier.doi10.1161/01.STR.0000206153.92675.b9
dc.identifier.endpage1027en_US
dc.identifier.issn0039-2499
dc.identifier.issn1524-4628
dc.identifier.issue4en_US
dc.identifier.pmid16497978
dc.identifier.scopus2-s2.0-33645817290
dc.identifier.scopusqualityQ1
dc.identifier.startpage1021en_US
dc.identifier.urihttps://doi.org/10.1161/01.STR.0000206153.92675.b9
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3604
dc.identifier.volume37en_US
dc.identifier.wosWOS:000236292100023
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofStroke
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectaneurysmen_US
dc.subjectgeneticsen_US
dc.titleMolecular genetic analysis of two large kindreds with intracranial aneurysms demonstrates linkage to 11q24-25 and 14q23-31en_US
dc.typeArticle

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