Alkaline phosphatase, cytokeratin 7, cytokeratin 8 in the diagnosis of primary lung adenocarcinoma from 148 pleura fluids specimens

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dc.contributor.authorSerpil, Oğuztüzün
dc.contributor.authorMeral, Atay
dc.contributor.authorMuzeyyen, Özhavzali
dc.contributor.authorÖzlem, Temelli
dc.contributor.authorÜmit, Yırtıcı
dc.contributor.authorMustafa, Türk
dc.contributor.authorZiya, Atay
dc.date.accessioned2020-06-25T17:48:48Z
dc.date.available2020-06-25T17:48:48Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAdenocarcinomas are the most common cause of malignancy in pleura fluids. Usual primary sites include the lung, breast, gastrointestinal tract, and genitourinary tracts. Predicting the site of origin of an adenocarcinoma can be difficult due to overlapping morphologic characteristics. We investigated the use of alkaline phosphatase (AP), Cytokeratin7 (CK7) Cytokeratin8 (CK8) to distinguish adenocarcinomas of lung in 148 body cavity fluid samples. Overall results for primary lung adenocarcinomas, demonstrated CK8 reactivity in 106 (72%) of 148 cases. 95 primary lung carcinoma samples (65%) were positive for CK7. AP was expressed in 81% of primary lung adenocarcinomas. Positive immunoreactivity for AP was characterized by a red, diffusely apical cytoplasmic staining in tumor cells that ocurred singly or in groups. There was a significant difference between AP, CK 7 and CK 8 expressions in primary lung adenocarcinomas (P=0.02; Chi-squared test). The sensitivity of AP, CK8, CK7 as a marker for primary lung adenocarcinomas were 82%, 72%, 64%, respectively. Thus the AP positive staining largely confirmed the cytologic diagnosis of lung adenocarcinoma.en_US
dc.identifier.citationSerpil, O., Meral, A., Müzeyyen, O., Ozlem, T., Umit, Y., Mustafa, T., & Ziya, A. (2009). Alkaline phosphatase, cytokeratin 7, cytokeratin 8 in the diagnosis of primary lung adenocarcinoma from 148 pleura fluids specimens. Folia histochemica et cytobiologica, 47(1), 87–92. https://doi.org/10.2478/v10042-009-0001-7en_US
dc.identifier.doi10.2478/v10042-009-0001-7
dc.identifier.endpage92en_US
dc.identifier.issn0239-8508
dc.identifier.issn1897-5631
dc.identifier.issue1en_US
dc.identifier.pmid19419944
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.2478/v10042-009-0001-7
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4561
dc.identifier.volume47en_US
dc.identifier.wosWOS:000282021000014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Histochemica Et Cytobiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectlung adenocarcinomaen_US
dc.subjectalkaline phosphataseen_US
dc.subjectcytokeratine 7en_US
dc.subjectcytokeratine 8en_US
dc.subjectimmunocytochemistryen_US
dc.subjectbody cavity fluidsen_US
dc.titleAlkaline phosphatase, cytokeratin 7, cytokeratin 8 in the diagnosis of primary lung adenocarcinoma from 148 pleura fluids specimensen_US
dc.typeArticle

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