Investigation of the effects of thymoquinone on erythrocyte deformability in sepsis treatment which created by cecal perforation in rat

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dc.contributor.authorBostanci, H.
dc.contributor.authorDikmen, K.
dc.contributor.authorComu, F. M.
dc.contributor.authorArslan, M.
dc.contributor.authorKucuk, A.
dc.date.accessioned2020-06-25T18:30:07Z
dc.date.available2020-06-25T18:30:07Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractAIM: We aimed to study the effects of thymoquinone on erythrocyte deformability in an experimental model of sepsis given before or after the initiation of the sepsis model. METHOD: The animals were grouped as (n = 6) control, nigella sativa, sepsis, sepsis group with administration of nigella sativa before sepsis development and sepsis group with nigella sativa administration after sepsis development. Cecal ligation and puncture model (CLP) was used to induce sepsis in the animals. The thymoquinone was given 1 hour before or after the CLP in the study groups with a dose of 500 mg.kg(-1). Erythrocyte deformability and relative resistance was calculated. RESULT: Relative resistance was increased in the sepsis groups when compared to the control group (p < 0.0001). Deformability index was increased in the sepsis group when compared to the other groups (p < 0.0001 in all groups). Sepsis group with after nigella sativa groups deformability index was significantly different from the deformability index in control group (p = 0.002). The use of nigella sativa before the initiation of sepsis corrected the deformability index significantly and the results were comparable to the control group (p = 0.078). CONCLUSION: Thymoquinone administration before induction of CLP was observed to have protective effects on these alterations in CLP sepsis (Tab. 1, Fig. 1, Ref. 26). Text in PDF www.elis.sk.en_US
dc.identifier.citationBostanci, H., Dikmen, K., Comu, F. M., Arslan, M., & Kucuk, A., (2018). Investigation of the effects of thymoquinone on erythrocyte deformability in sepsis treatment which created by cecal perforation in rat. BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY , vol.119, no.3, 152-155.en_US
dc.identifier.doi10.4149/BLL_2018_029
dc.identifier.endpage155en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue3en_US
dc.identifier.pmid29536743
dc.identifier.scopus2-s2.0-85044402174
dc.identifier.scopusqualityQ2
dc.identifier.startpage152en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2018_029
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7566
dc.identifier.volume119en_US
dc.identifier.wosWOS:000428649600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsepsisen_US
dc.subjectcecal ligation and perforationen_US
dc.subjectthymoquinoneen_US
dc.subjecterythrocyte deformabilityen_US
dc.titleInvestigation of the effects of thymoquinone on erythrocyte deformability in sepsis treatment which created by cecal perforation in raten_US
dc.typeArticle

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