The relationship between serum sex steroid levels and heart rate variability parameters in males and the effect of age

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dc.contributor.authorDoğru M.T.
dc.contributor.authorBaşar M.M.
dc.contributor.authorYuvanç E.
dc.contributor.authorŞimşek V.
dc.contributor.authorŞahin Ö.
dc.date.accessioned2020-06-25T15:14:30Z
dc.date.available2020-06-25T15:14:30Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: We evaluated the relationships between sex steroid levels and heart rate variability (HRV) parameters. Study design: The study included 114 male subjects (mean age 46.6±11.3 years) presenting to our department for cardiologic evaluation. Hormonal analysis included serum levels of luteinizing hormone, prolactin, total testosterone (TT), free testosterone, estradiol (E2), and dehydroepiandrosterone sulfate (DHEA-S). Parameters of HRV were derived from 24-hour Holter monitoring. The associations between serum sex steroid levels and HRV parameters were investigated in three age groups (20-39 years; 40-59 years; >60 years). Results: All the participants had normal biochemical results. The three age groups were similar in terms of anthropometric measurements. Among sex steroids analyzed, only serum DHEA-S level was significantly different among the groups (p=0.026), showing a decreasing trend with age. In the evaluation of HRV, all parasympathetic activities decreased (for HFn, pNN50, and rMSDD: p=0.001, p=0.000, and p=0.000, respectively), while only LF/HF among sympathetic activities increased (p=0.000) with age. Partial correlation analysis with control of age and waist circumference showed that TT and DHEA-S were positively correlated with HF n (parasympathetic parameter), and were in negative correlation with LF/HF24 hours and global sympathetic index (GSI) (sympathetic parameters). Serum E2 level was negatively correlated with the parasympathetic parameter of rMSSD, and positively correlated with LF/HF24 hours and GSI. Among serum sex steroids, DHEA-S was the most correlated parameter with autonomic functions. Conclusion: Our results showed positive correlations between androgens and parasympathetic activity and between estradiol and sympathetic activity in men, independent from anthropometric factors.en_US
dc.identifier.citationDoğru, M. T., Başar, M. M., Yuvanç, E., Şimşek, E., Şahin, Ö. (2010). The relationship between serum sex steroid levels and heart rate variability parameters in males and the effect of age. Türk Kardiyoloji Derneği Arşivi, 38(7), 459 - 465.en_US
dc.identifier.endpage465en_US
dc.identifier.issn10165169
dc.identifier.issue7en_US
dc.identifier.pmid21206198
dc.identifier.scopus2-s2.0-79955622789
dc.identifier.scopusqualityQ3
dc.identifier.startpage459en_US
dc.identifier.trdizinid112062
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2127
dc.identifier.volume38en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAndrogensen_US
dc.subjectDehydroepiandrosteroneen_US
dc.subjectElectrocardiography, ambulatoryen_US
dc.subjectEstradiolen_US
dc.subjectGonadal steroid hormonesen_US
dc.subjectHeart rateen_US
dc.subjectMaleen_US
dc.subjectTestosteroneen_US
dc.titleThe relationship between serum sex steroid levels and heart rate variability parameters in males and the effect of ageen_US
dc.typeArticle

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