The possible mechanisms of the human microbiome in allergic diseases

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dc.contributor.authorIpci, Kagan
dc.contributor.authorAltintoprak, Niyazi
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorSenturk, Mehmet
dc.contributor.authorCingi, Cemal
dc.date.accessioned2020-06-25T18:23:13Z
dc.date.available2020-06-25T18:23:13Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn the present paper, we discuss the importance of the microbiome in allergic disease. In this review paper, the data from the Medline (PubMed) and search engine of Kirikkale University were systematically searched for all relevant articles in June 15th, 2015 for the past 30 years. The keywords of "microbiome'', "dysbiosis'', "allergy'', "allergic rhinitis'', "allergic disease'', "mechanisms'' and "treatment'' were used alone or together. In this paper, microbiomes were presented in terms of "Definition'', "Influence of \the human microbiome on health'', "The microbiome and allergic diseases'', and "Modulation of the gut microbiota in terms of treatment and prevention''. Microbiological dysbiosis is also reviewed. The microbiome is the genetic material of all microbes (bacteria, fungi, protozoa, and viruses) that live on or in the human body. Microbes outnumber human cells in a 10: 1 ratio. Most microbes live in the gut, particularly the large intestine. Changes in the immune function of the respiratory tract are (at least in theory) linked to the immunomodulatory activity of the gut microbiota via the concept of a "common mucosal response''. The gut microbiota shapes systemic immunity, thus affecting the lung mucosa. Alternatively, changes in the gut microbiota may reflect alterations in the oropharyngeal microbiota, which may in turn directly affect the lung microbiota and host immune responses via microaspiration. Dysbiosis is defined as qualitative and quantitative changes in the intestinal flora; and modern diet and lifestyle, antibiotics, psychological and physical stress result in alterations in bacterial metabolism, as well as the overgrowth of potentially pathogenic microorganisms. All immune system components are directly or indirectly regulated by the microbiota. The nature of microbial exposure early in life appears to be important for the development of robust immune regulation; disruption of either the microbiota or the host response can trigger chronic inflammation. Dysbiosis is also an important clinical entity. Antibiotics, psychological and physical stress, and dietary factors contribute to intestinal dysbiosis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00405-016-4058-6
dc.identifier.endpage626en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue2en_US
dc.identifier.pmid27115907
dc.identifier.scopus2-s2.0-84964526810
dc.identifier.scopusqualityQ1
dc.identifier.startpage617en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-016-4058-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7044
dc.identifier.volume274en_US
dc.identifier.wosWOS:000394351800003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngology
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrobiomeen_US
dc.subjectImmune systemen_US
dc.subjectImmunomodulatory activityen_US
dc.subjectB cell maturationen_US
dc.subjectGut microbiotaen_US
dc.subjectDysbiosisen_US
dc.titleThe possible mechanisms of the human microbiome in allergic diseasesen_US
dc.typeReview Article

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