Is there a relation between mean platelet volume and chronic kidney disease stages in diabetic patients?

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dc.contributor.authorYenigun, Ezgi Coskun
dc.contributor.authorAypak, Cenk
dc.contributor.authorTurgut, Didem
dc.contributor.authorPiskinpasa, Serhan Vahit
dc.contributor.authorCevher, Simal Koksal
dc.contributor.authorKoc, Eyup
dc.contributor.authorDede, Fatih
dc.date.accessioned2020-06-25T18:22:29Z
dc.date.available2020-06-25T18:22:29Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Chronic kidney disesase (CKD) is a state of atherosclerotic and chronic inflammation and as the estimated glomerular filtration rate (GFR) declines, cardiovascular disease (CVD) risk and inflammation increase. Mean platelet volume (MPV) has shown to be influenced by cardiovascular risk factors. The aim of this study was to evaluate the relationship between MPV and CKD. Methods: This is prospective study of a total of 812 CKD patients. Patients with CKD were assigned to into the five groups depending on estimated GFR which were calculated by Modification of Diet in Renal Disease (MDRD). Patients demographics, comorbid disease were recorded, and laboratory variables were also evaluated. Results: The mean age of CKD patients was 62.6 +/- 15.4 years. According to stages, 96 patients (11.8%) were classified as stage 1 (GFR >90 ml/min/1.73 m(2)), 77 patients (9.5%) as stage 2 (GFR 89-60 ml/min/1.73 m(2)), 306 patients (37.7%) as stage 3 (GFR 59-30 ml/min/1.73 m(2)), 198 (24.4%) patients as stage 4 (GFR 29-15 ml/min/1.73 m(2)) and 135 (16.6%) patients as stage 5 (GFR < 15 ml/min/1.73 m(2), dialysis and non-dialysis). DM was found to be positive in 299 (152 female; 147 male) patients. The mean MPV was found to higher in diabetic patients compared to non-diabetic patients (9.5 +/- 1.3 fL vs 9.3 +/- 1.4 fL, p: 0.024). There was a positive correlation between CKD stage and MPV in diabetic male patients. Conclusion: The results of our study might suggest that diabetic male patients with CKD have higher MPV values support the idea that these groups have additional risks other than CKD and these patients should be followed closely in respect to its complications.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage335en_US
dc.identifier.issn1940-5901
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84957562317
dc.identifier.scopusqualityN/A
dc.identifier.startpage330en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6762
dc.identifier.volume9en_US
dc.identifier.wosWOS:000371356600042
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectmean platelet volumeen_US
dc.subjectdiabetes mellitusen_US
dc.titleIs there a relation between mean platelet volume and chronic kidney disease stages in diabetic patients?en_US
dc.typeArticle

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