Investigation of Thiol/Disulfide Balance in Obese Rats with Non-Alcoholic Fatty Liver Disease

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dc.authoridneselioglu, salim/0000-0002-0974-5717
dc.authoridSahin, Yasar/0000-0001-5936-4210
dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.contributor.authorTursun, Serkan
dc.contributor.authorGulerman, Hacer Fulya
dc.contributor.authorGazyagci, Serkal
dc.contributor.authorSahin, Yasar
dc.contributor.authorErel, Ozcan
dc.contributor.authorNeselioglu, Salim
dc.date.accessioned2025-01-21T16:42:14Z
dc.date.available2025-01-21T16:42:14Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose: Due to the increasing prevalence of obesity worldwide, non-alcoholic fatty liver disease (NAFLD) has reached epidemic dimensions over time. NAFLD is the most common cause of childhood chronic liver disease. There is a relationship between NAFLD and oxidative stress. This study aims to investigate the changes in thiol/disulfide homeostasis parameters to determine the oxidant/antioxidant balance in obese rats with diet-induced NAFLD and healthy rats. Methods: Twelve Wistar albino rats were used in this study. Experimentally produced NAFLD obese rats (n=6) and healthy rats were compared. Experimental NAFLD model was created with a special fatty liver diet (Altromin (R) C1063, Fatty Liver Diet, Exclusivet, Lage, Germany). The biochemical and histopathological features of the groups, as well as serum thiol/disulfide homeostasis parameters, were analyzed and compared. Results: In the experimentally induced NAFLD rat model, they gained more weight than the control group. Steatosis (at least grade 2) occurred in all rats fed with special fatty liver diet for 12 weeks. Histopathologically, no high-grade inflammation was observed in rats with experimental NAFLD after feeding a diet for 12 weeks. Results revealed that aspartate transaminase and alanine transaminase levels were high, albumin levels were low, oxidant stress parameters increased, and antioxidant thiol groups decreased. Conclusion: Experimental NAFLD is characterized by increased oxidant stress accompanying fatty tissue in the liver. Analysis of thiol/disulfide homeostasis parameters in NAFLD can be used in further studies to develop effective treatment options.
dc.description.sponsorshipKirikkale University [2018/072]
dc.description.sponsorshipThis study was carried out with the support of Kirikkale University scientific research projects coordination unit (Project number: 2018/072).
dc.identifier.doi10.5223/pghn.2021.24.5.443
dc.identifier.endpage454
dc.identifier.issn2234-8646
dc.identifier.issn2234-8840
dc.identifier.issue5
dc.identifier.pmid34557397
dc.identifier.scopus2-s2.0-85116901390
dc.identifier.scopusqualityQ2
dc.identifier.startpage443
dc.identifier.urihttps://doi.org/10.5223/pghn.2021.24.5.443
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25025
dc.identifier.volume24
dc.identifier.wosWOS:000698511400004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Soc Pediatric Gastroenterology & Nutrition
dc.relation.ispartofPediatric Gastroenterology Hepatology & Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectFatty liver; Obesity; Oxidative stress; Sulfhydryl compounds; Disulfides; Rats
dc.titleInvestigation of Thiol/Disulfide Balance in Obese Rats with Non-Alcoholic Fatty Liver Disease
dc.typeArticle

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