Serum soluble CD30 levels in Behçet's disease

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dc.contributor.authorDüzgün, Nursen
dc.contributor.authorAyaslioglu, Ergin
dc.contributor.authorTutkak, Hüseyin
dc.date.accessioned2020-06-25T15:13:21Z
dc.date.available2020-06-25T15:13:21Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBehçet's disease is associated with the inflammatory response. Several reports indicate the presence of primarily CD4+ T cells of the Th1 subtype in the inflammation process of the disease. Serum soluble CD30 (sCD30) is reported to be released from CD4+ Th2 type cells and has been suggested to be a marker of Th2 activity. In this study, serum sCD30 levels were measured in active and inactive patients with Behçet's disease, healthy controls and a group of patients with rheumatoid arthritis, typical Th1 disorder using enzyme immunoassay kit. Mean sCD30 value of 54 active patients were found significantly higher than in those of 17 inactive patients (p = 0.027), 20 healthy controls (p = 0.040) and 25 patients with rheumatoid arthritis (p < 0.001). There was a significant correlation between increased sCD30 levels and clinical activity index in active patients with Behçet's disease. High serum levels of sCD30 may reflect the activation qf CD4+ T cells or a subset of them in active BD patients. In addition to serum sCD30 levels, measurements of the Th2 cytokines may be a helpful tool for the evaluation of Th2 activity in Behçet's disease. © Copyright Clinical and Experimental Rheumatology 2004.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpageS20en_US
dc.identifier.issn0392856X
dc.identifier.issue4 SUPPL. 24en_US
dc.identifier.pmid15515777
dc.identifier.scopus2-s2.0-5444268071
dc.identifier.scopusqualityQ2
dc.identifier.startpageS17en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1752
dc.identifier.volume22en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofClinical and Experimental Rheumatology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehçet's diseaseen_US
dc.subjectDisease activityen_US
dc.subjectSoluble CD30en_US
dc.titleSerum soluble CD30 levels in Behçet's diseaseen_US
dc.typeArticle

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