Effect of dexmedetomidine on erythrocyte deformability during ischemia-reperfusion injury of liver in diabetic rats

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dc.contributor.authorArslan, M.
dc.contributor.authorComu, F. M.
dc.contributor.authorIsik, B.
dc.contributor.authorOzturk, L.
dc.contributor.authorKesimci, E.
dc.date.accessioned2020-06-25T18:06:44Z
dc.date.available2020-06-25T18:06:44Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractAim: The aim of this study is to evaluate the effect of dexmedetomidine on erythrocyte deformability during IR injury of liver in diabetic rats. Methods: Twenty-eight Wistar Albino rats were included in the study after a 4 week streptozocin (65 mg/kg) treatment to observe the existence of diabetes. The animals were randomly assigned to one of the four experimental groups: GroupC and DC (sham-control group): The abdomen was dissected with a median laparotomy and the liver was collected. GroupDIR: The liver was collected after IR following the abdominal median laparotomy. GroupDIRD: The liver was collected after IR following the abdominal median laparotomy and 30 min of infusion of dexmedetomidine 100 mu g/kg ip The deformability measurements were performed in erythrocyte suspensions containing Htc 5% in PBS buffer. Results: The deformability index was significantly increased in diabetic rats, however it was similar in the GroupC and DIRD. It was significantly increased in the GroupDIR when compared to the GroupC, DIRD and DC. The relative resistance was increased in IR models. Conclusion: Erythrocyte deformability was damaged in rats having diabetes and IR injury. This injury might lead to further problems in microcirculation. It was shown that dexmedetomidine may be useful in enhancing the adverse effects of this injury (Tab. 1, Fig. 2, Ref. 41). Full Text in PDF www.elis.sk.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.4149/BLL_2012_156
dc.identifier.endpage691en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue12en_US
dc.identifier.pmid23173624
dc.identifier.scopus2-s2.0-84871745172
dc.identifier.scopusqualityQ2
dc.identifier.startpage687en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2012_156
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5333
dc.identifier.volume113en_US
dc.identifier.wosWOS:000312349000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectischemia reperfusionen_US
dc.subjectalpha(2) agonisten_US
dc.subjectexperimental diabetesen_US
dc.subjectdexmedetomidineen_US
dc.subjectraten_US
dc.titleEffect of dexmedetomidine on erythrocyte deformability during ischemia-reperfusion injury of liver in diabetic ratsen_US
dc.typeArticle

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