Bioactivity of extracts of Centaurea polyclada dc. (Asteraceae)

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dc.contributor.authorGranger, Melanie
dc.contributor.authorSamson, Emilie
dc.contributor.authorSauvage, Severine
dc.contributor.authorMajumdar, Anisha
dc.contributor.authorNigam, Poonam
dc.contributor.authorNahar, Lutfun
dc.contributor.authorSarker, Satyajit D.
dc.date.accessioned2020-06-25T17:48:44Z
dc.date.available2020-06-25T17:48:44Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe free radical-scavenging property, antibacterial activity, and brine shrimp toxicity of n-hexane, dichloromethane (DCM), and methanol (MeOH) extracts of Centaurea polyclada, an endemic Turkish species, were assessed using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the resazurin microtiter plate-based assay, and the brine shrimp lethality assay, respectively. The DCM and MeOH extracts of C. polyclada exhibited free radical-scavenging ability with RC50 values 1.17 and 0.015 mg/mL, respectively. Among solid-phase extraction fractions of the MeOH extract, the fraction eluted with 60% MeOH in water demonstrated the highest level of free radical-scavenging activity (RC50 = 0.016 mg/mL). Only the DCM extract showed considerable antibacterial activity against all nine test strains except Escherichia coli, with MIC ranging from 1.25 to 2.50 mg/mL. This antibacterial activity pattern was also observed with solid-phase extraction fractions of the DCM extract with varied potencies. None of the extracts showed any significant toxicity towards brine shrimps (LD50 = >1.00 mg/mL).en_US
dc.identifier.citationGranger, M., Samson, E., Sauvage, S., Majumdar, A., Singh - Nee Nigam, P., Nahar, L., Celik, S., & Sarker, S. D. (2009). Bioactivity of extracts of Centaurea polyclada dc. (Asteraceae). ARCHIVES OF BIOLOGICAL SCIENCES, 61(3), 447-452. https://doi.org/10.2298/ABS0903447Gen_US
dc.identifier.doi10.2298/ABS0903447G
dc.identifier.endpage452en_US
dc.identifier.issn0354-4664
dc.identifier.issn1821-4339
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-77949495902
dc.identifier.scopusqualityQ3
dc.identifier.startpage447en_US
dc.identifier.urihttps://doi.org/10.2298/ABS0903447G
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4542
dc.identifier.volume61en_US
dc.identifier.wosWOS:000269654300011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInst Bioloska Istrazivanja Sinisa Stankovicen_US
dc.relation.ispartofArchives Of Biological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCentaurea polycladaen_US
dc.subjectAsteraceaeen_US
dc.subjectfree radical-scavenging activityen_US
dc.subjectantioxidanten_US
dc.subjectantibacterialen_US
dc.subjectresazurin assayen_US
dc.subjectDPPHen_US
dc.subjectbrine shrimp lethality assayen_US
dc.titleBioactivity of extracts of Centaurea polyclada dc. (Asteraceae)en_US
dc.typeArticle

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